Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 128-130.doi: 10.6040/j.issn.1673-3770.0.2018.242

Previous Articles     Next Articles

Clinical effect of budesonide nasal irrigation shortly after functional endoscopic endonasal surgery of chronic sinusitis

ZHANG Wei1, LIU Yonggang2, JIANG Lingyan1   

  1. Ophthalmology Hospital of Chinese Academy of Chinese Medical Sciences, Beijing 100040, China
  • Online:2019-01-20 Published:2019-01-28

PDF (PC)

446

Abstract: Objective To investigate the therapeutic effectiveness and feasibility of budesonide nasal irrigation shortly after Functional Endoscopic sinus surgery(FESS)of chronic sinusitis by observing the recovery of the nasal mucosa. Methods Fifty-five participants with chronic rhino-sinusitis were divided into treated(budesonide and saline irrigation)and control(saline irrigation)groups according to irrigation contents twice daily. VAS(nose obstruction, nasal discharge, smelling, and facial pain)and Kennedy scores were collected before FESS, while LKES and SNOT-22 scores were collected and compared before and after nasal irrigation. Results VAS scores were 17.80±3.22 in the treated group and 18.66±3.43 in the control group(P<0.05). Kennedy scores were 3.45±1.09 in the treated group and 3.37±1.05 in the control group(P<0.05). Scores of LKES and SNOT-22 were compared between the treated and control groups(P<0.05). There were no adverse events during treatment and irrigation. Conclusions Nasal symptoms shortly after FESS could be improved with budesonide irrigation, especially by reducing nasal mucositis after surgery and promoting nasal mucosa recovery.

Key words: Sinusitis, Budesonide, Nasal irrigation, Functional endoscopic surgery

CLC Number: 

  • R765.41
[1] 中华医学会放射学分会头颈学组.鼻部CT和MRI检查及诊断专家共识[J].中华放射学杂志,2017,51(9):660-664. doi:10.3760/cma.j.issn.1005-1201.2017.09.006
[2] Expert panel on Neurologic Imaging. ACR Appropriateness Criterita Sinonasal Disease[J]. J Am Coll Radiol, 2017, 14:S550-S559.
[3] 王成硕, 张罗. 慢性鼻窦炎的治疗策略[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(14):1175-1178. doi:10.13201/j.issn.1001-1781.2016.14.024. WANG Chengshuo, ZHANG Luo. Management of chronic rhinosinusitis[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2016, 30(14):1175-1178. doi:10.13201/j.issn.1001-1781.2016.14.024.
[4] Lund VJ, Kennedy DW. Staging for rhinosinusitis[J]. Otolaryngol Head Neck Surg, 1997, 117(3 Pt 2):S35-S40. doi:10.1016/S0194-59989770005-6.
[5] Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline(update): adult sinusitis[J]. Otolaryngol Head Neck Surg, 2015, 152(2 Suppl):S1-S39. doi:10.1177/0194599815572097.
[6] Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists[J]. Rhinology, 2012, 50(1):1-12. doi:10.4193/Rhino50E2.
[7] 李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3):4-9. doi:10.6040/j.issn.1673-3770.1.2018.004. LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3):4-9. doi:10.6040/j.issn.1673-3770.1.2018.004.
[8] 许庚, 李源, 谢民强. 功能性内窥镜鼻窦手术后术腔粘膜转归阶段的划分及处理原则[J]. 中华耳鼻咽喉科杂志, 1999, 34(5): 302. doi:10.3760/j.issn:1673-0860.1999.05.018.
[9] Adappa ND, Wei CC, Palmer JN. Nasal irrigation with or without drugs: the evidence[J]. Curr Opin Otolaryngol Head Neck Surg, 2012, 20(1):53-57. doi:10.1097/moo.0b013e32834dfa80.
[10] Snidvongs K, Pratt E, Chin D, et al. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2012, 2(5):415-421. doi:10.1002/alr.21047.
[11] 唐力行, 高娟, 张亚梅. 布地奈德盐水鼻腔冲洗治疗儿童鼻-鼻窦炎疗效分析[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(12):952-954,959. doi:10.13201/j.issn.1001-1781.2016.12.008. TANG Lixing, GAO Juan, ZHANG Yamei. Budesonide saline nasal irrigation in treatment of children rhino-sinusitis[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2016, 30(12):952-954,959. doi:10.13201/j.issn.1001-1781.2016.12.008.
[12] Kang TW, Chung JH, Cho SH, et al. The effectiveness of budesonide nasal irrigation after endoscopic sinus surgery in chronic rhinosinusitis with asthma[J]. Clin Exp Otorhinolaryngol, 2017, 10(1):91-96. doi:10.21053/ceo.2016.00220.
[13] 娄鸿飞, 王成硕, 张罗. 经鼻雾化吸入布地奈德混悬液和口服激素治疗慢性鼻-鼻窦炎鼻息肉的疗效及安全性的对比研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(9): 792-796. doi:10.13201/j.issn.1001-1781.2015.09.006. LOU Hongfei, WANG Chengshuo, ZHANG Luo. The efficacy and safety of budesonide inhalation suspension via transnasal nebulization compared with oral corticosteroids in chronic rhinosinusitis with nasal polyps[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2015, 29(9):792-796. doi:10.13201/j.issn.1001-1781.2015.09.006.
[1] FENG Sicong, YU Xiaolan, LOU Dan. Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 31-39.
[2] ZHAI Xuechun, BIAN Xin, CHEN Jingcai, DENG Jiayu, YE Zi, YANG Pingli. Characteristics and influencing factors of anxiety and depression in patients with chronic frontal sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 35-43.
[3] LI Yangsong, YUAN Fayang, YANG Yan, ZHANG Tian, YU Guodong. Bibliometric analysis of biologic agents for the treatment of chronic rhinosinusitis based on the Web of Science database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 54-64.
[4] DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86.
[5] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[6] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[7] ZHANG Jiaqi, YUAN Ye, HONG Chen, GU Min, CHENG Lei, LU Meiping. Mendelian randomization study of gut microbiota, chronic sinusitis, and nasal polyps: Causal relationships and metabolite-mediated effects [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 49-60.
[8] ZHANG Guangling, CHEN Xingxue, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao,WANG Guangke. The expression and function of Tespa1 in chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 35-42.
[9] CAO Zhengyong, LI Xiaobo. Comparison of the safety and efficacy of short-course postoperative topical glucocorticoid adjuvant therapy for eCRSwNP combined with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 43-50.
[10] WANG Wenqing, ZHANG Dan, ZHU Mengdi, WANG Luyang, YANG Peipei, SUN Sisi, ZHANG Qiumin, ZHOU Hui. Changes of clinical and histopathological characteristics in recurrent chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 46-53.
[11] WANG Aowei, SHI Wenjie. Study on correlation between traditional Chinese medicine syndrome types and TFH cell related factors in CRSwNP [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 54-60.
[12] ZHANG Jie, NIMA Jizong, XU Xiaodong, ZHOU Jing, LIU Jianmin, LUO Yirui, DU Jintao, BA Luo. Effect of Crocin on Type 2 inflammation in eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 61-67.
[13] ZHANG Yunqiu, REN Xiumin, XU Ou, DONG Jinhui, WANG Jianxing. Research progress on omalizumab targeted therapy for chronic sinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 136-140.
[14] LI Ting, ZHAO Chong, WU Xian. The relationship between miR-34a expression in nasal mucosa tissue and postoperative recurrence in patients with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 20-25.
[15] CHEN Xingxue, ZHANG Guangling, WU Tianyi, WANG Weiwei, SUN Zhanwei, LI Shichao, WANG Guangke. Analysis of anti-IL-4Rα monoclonal antibody and endoscopic sinus surgery in the treatment of eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 43-54.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd