Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (5): 132-137.doi: 10.6040/j.issn.1673-3770.0.2020.352

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Expression of cyclin E2 in hypopharyngeal cancer and its clinical significance

  

  • Received:2020-08-05 Published:2020-11-17

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Abstract: Objective This study aims to evaluate the level of expression of cyclin E2 in hypopharyngeal cancer and its relationship with clinical characteristics as well as prognosis. Methods The protein levels of cyclin E2 in tumor tissues and adjacent normal tissues were assessed by immunohistochemistry staining in 50 cases of hypopharyngeal cancer. The relationship between the expression level of cyclin E2 and clinical data was analyzed using the SPSS software. Results Protein levels of cyclin E2 in hypopharyngeal cancer were higher than protein levels of cyclin E2 in normal tissue(Z=-5.764,P=0.000). The cyclin E2 level in tumor tissue correlated with the tumor staging(Z=-1.995, P=0.046)and lymph node metastasis(Z=-2.176, P=0.030). The 5-year survival rates of patients with cyclin E2 positive and negative expression were 40.2% and 81.8%, respectively. Patients with high expression levels of cyclin E2 had a lower survival rate(χ2=6.317, P=0.012). Conclusion The abnormal expression of cyclin E2 protein in tumor tissues indicates that cyclin E2 may be involved in the development of hypopharyngeal cancer and could be a potential diagnostic and prognostic molecular marker.

Key words: Cyclin E2, Hypopharyngeal carcinoma, Database retrieval, Immunohistochemistry, Survival analysis, Prognosis factor

CLC Number: 

  • R739.63
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