Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (2): 136-140.doi: 10.6040/j.issn.1673-3770.0.2020.285

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Current progress of exosome research in allergic diseases

ZHANG Xuping1,2, LIU Xuexia3Overview,ZHANG Hua2Guidance   

  1. 1. Binzhou Medical University, Binzhou 256600, Shandong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China;
    3. Central Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China
  • Published:2021-04-20

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Abstract: Exosomes are closed vesicles with a lipid bilayer membrane that are produced from late endosomes. They can carry and secrete cargo such as intracellular proteins and nucleic acids, and they can be transported to recipient cells. Exosomes are used for signal transduction and intercellular communication. These carriers play an important role in various physiological and pathological processes. Recent studies have found that exosomes can regulate immune responses, transmit inflammatory signals, and release cytokines, which play a key role in allergic diseases. Since exosomes exist in a variety of body fluids, they are expected to aid early disease screening, efficacy evaluation, and prognostic analysis. Therefore, this study reviews the research progress regarding exosomes in allergic diseases, hoping to provide new ideas and effective targets for the diagnosis and treatment of diseases.

Key words: Exosomes, allergy, Inflammation, Intercellular communication, miRNA

CLC Number: 

  • R765
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