Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (4): 35-39.doi: 10.6040/j.issn.1673-3770.0.2021.140

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Laryngeal involvement in progressive nodular histiocytosis: a case report with literature review

LIAO Jingwen1, CHEN Min1, LI Na1, HUANG Yichuan1, ZHAO Han2   

  1. Affiliated Hospital of Qingdao University 1.Department of Otorhinolaryngology & Head and Neck Surgery;
    2. Department of Pathology Qingdao 266071, Shandong, China;
  • Published:2021-08-05

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Abstract: Objective To explore the diagnosis and treatment, the clinical characteristic, as well as the pathological features, of a rare case of progressive nodular histiocytosis involving the larynx. Methods Patient case data, pathological sections were extracted and observed by immunohistochemical staining to summarize the characteristics of this case and to consult the literature related to PNH. Results The pathology of the patient in this case suggested a diffuse infiltration of spindle cells, and immunohistochemistry was positive for CD68 and CD163. The patient presented with supraglottic stenosis, thickening of the tracheal wall, and multiple nodules in the trachea. The patient had undergone a tracheotomy due to dyspnea. This disease involves the skin, and it manifests in multiple nodules and facial nodules that give rise to a “lion face” appearance. After diagnosis, treatment with anlotinib can delay the development of this disease. Conclusion The disease is diagnosed based on pathological examination. It can involve the larynx and cause breathing difficulties. Surgical removal of the facial nodules is not recommended unless body function is seriously affected.

Key words: Histiocytosis, Non-neoplastic proliferative skin disease, Non-Langerhans cell histiocytosis, Laryngeal

CLC Number: 

  • R758.6
[1] Taunton OD, Yeshurun D, Jarratt M. Progressive nodular histiocytoma[J]. Arch Dermatol, 1978, 114(10): 1505-1508.
[2] 渠涛, 方凯. 进行性结节性组织细胞增生症[J]. 临床皮肤科杂志, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022. QU Tao, FANG Kai. Progressive nodular Histiocytosis: a case report and literature review[J]. J Clin Dermatol, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022.
[3] Chu AC. The confusing state of the histiocytoses[J]. Br J Dermatol, 2000, 143(3): 475-476. doi:10.1111/j.1365-2133.2000.03821.x.
[4] Glavin FL, Chhatwall H, Karimi K. Progressive nodular Histiocytosis: a case report with literature review, and discussion of differential diagnosis and classification[J]. J Cutan Pathol, 2009, 36(12): 1286-1292. doi:10.1111/j.1600-0560.2009.01454.x.
[5] Amin SM, Riddle C, Fraga GR, et al. Progressive nodular Histiocytosis with normal karyotypic analysis[J]. Dermatol Online J, 2013, 19(6): 18577.
[6] Nofal A, Assaf M, Tawfik A, et al. Progressive nodular Histiocytosis: a case report and literature review[J]. Int J Dermatol, 2011, 50(12): 1546-1551. doi:10.1111/j.1365-4632.2011.04904.x.
[7] Hilker O, Kovneristy A, Varga R, et al. Progressive nodular Histiocytosis[J]. J Ger Soc Dermatol: JDDG, 2013, 11(4): 301-307. doi:10.1111/j.1610-0387.2012.08069.x.
[8] Bratschi MW, Steinmann P, Wickenden A, et al. Current knowledge on Mycobacterium leprae transmission: a systematic literature review[J]. Lepr Rev, 2015, 86(2): 142-155.
[9] 程海星, 葛兰, 翟志芳, 等. 肉芽肿性蕈样肉芽肿[J]. 临床皮肤科杂志, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013. CHENG Haixing, GE Lan, ZHAI Zhifang, et al. A case of granulomatous mycosis fungoides[J]. J Clin Dermatol, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013.
[10] Spagnolo P, Renzoni EA, Wells AU, et al. C-C chemokine receptor 2 and sarcoidosis: association with Lofgren's syndrome[J]. Am J Respir Crit Care Med, 2003, 168(10): 1162-1166. doi:10.1164/rccm.200303-456OC.
[11] 王晓琴, 程岩峰, 韩秀萍. 皮肤结节病12例诊断与误诊分析[J]. 中国误诊学杂志, 2011, 11(3): 638.
[12] Gonzalez Ruíz A, Bernal Ruíz AI, Aragoneses Fraile H, et al. Progressive nodular Histiocytosis accompanied by systemic disorders[J]. Br J Dermatol, 2000, 143(3): 628-631. doi:10.1111/j.1365-2133.2000.03723.x.
[13] Watanabe T, Watanabe D, Tamada Y, et al. Progressive nodular Histiocytosis-A five-year follow up[J]. Eur J Dermatol, 2008, 18(2): 200-202. doi:10.1684/ejd.2008.0370.
[14] Huet F, Brenaut E, Costa S, et al. Progressive nodular Histiocytosis improved by methotrexate[J]. Eur J Dermatol, 2017, 27(6): 661-663. doi:10.1684/ejd.2017.3115.
[15] Williams A, Thomas AG, Kwatra KS, et al. Progressive nodular Histiocytosis associated with eale's disease[J]. Indian J Dermatol, 2015, 60(4): 388-390. doi:10.4103/0019-5154.160492.
[16] 王俊, 冉凤鸣, 金兵. 安罗替尼治疗恶性肿瘤的临床研究进展[J]. 中国肿瘤, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008. WANG Jun, RAN Fengming, JIN Bing. Progress on clinical research of anlotinib in cancer treatment[J]. China Cancer, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008.
[17] Wang LL, He Z, Yang S, et al. The impact of previous therapy strategy on the efficiency of anlotinib hydrochloride as a third-line treatment on patients with advanced non-small cell lung cancer(NSCLC): a subgroup analysis of ALTER0303 trial[J]. Transl Lung Cancer Res, 2019, 8(5): 575-583. doi:10.21037/tlcr.2019.09.21.
[18] Chi Y, Fang ZW, Hong XN, et al. Safety and efficacy of anlotinib, a multikinase angiogenesis inhibitor, in patients with refractory metastatic soft-tissue sarcoma[J]. Clin Cancer Res, 2018, 24(21): 5233-5238. doi:10.1158/1078-0432.CCR-17-3766.
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