JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

• Articles • Previous Articles     Next Articles

Long-term effect on auditory brain stem function of patients with nasopharyngeal carcinoma after radiotherapy

WU Xiang-ping   

  1. Department of Otolaryngology, Zhuzhou Kaide Hospital, Zhuzhou 412000, Hunan, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24
  • Contact: WU Xiang-ping

PDF (PC)

1674

Abstract: Objective： To investigate the longterm effect of radiotherapy on auditory brain stem function of patients with nasopharyngeal carcinoma(NPC). Methods： The auditory brain stem response(ABR) was examined in 33 patients (66 ears) with NPC before and at the first day, and on 3, 6, 12, 24 and 36 months after radiotherapy. Results： There were no obvious harmon auditory functions at the first day after radiotherapy. The auditory function decreased significantly at 6 months after radiotherapy and slightly recovered in the next 6 months, but after that it slightly decreased again. Conclusions： Conventional radiotherapy harms the auditory function in the longterm after treatment, so effective means should be adopted as early as possible.

Key words: auditory, Evoked potentials, brain stem, Nasopharyngeal neoplasms, Radiotherapy

CLC Number: 

  • R739.63
[1] NI Kun, SUN Shibing, LI Xiaoyan. Application of 1 000 Hz acoustic immittance in hearing screenings of high-risk newborns [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 43-47.
[2] PAN Linlin, KONG LingyiOverview,ZHAI Feng, CHEN JieGuidance. Research progress on auditory risk factors and hearing screening methods among neonates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 131-137.
[3] LI Yuanchao, WU Wei, WANG Gang, QU Changbei, WANG Lei, LU Wenjun, LI Dan, HAN Haolun, LIU Gang. Effects of simulated weightlessness and continuous noise in a spaceship on auditory function of rats [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 11-16.
[4] WEI Ya'nanOverview,CHEN XiGuidance. Progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 118-124.
[5] WANG Yingying, ZHOU Han, DONG Weida, XING Guangqian, CHEN Zhibin, ZHANG Qingzhao, ZHANG Liqing. Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 1-6.
[6] TAN Yufang, YI Tianhua. Clinical characteristics and prognosis of sudden sensorineural hearing loss in post-irradiated nasopharyngeal carcinoma survivors: a report of 18 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 35-39.
[7] GUO Fang, ZHANG Dejun, FU Zeming, GUO Yingyuan, WAN Yining, GUAN Guofang. Cholesteatoma of the external auditory canal complicated with suppurative parotitis: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 12-15.
[8] FAN Li, LI Yue, XU Ximing. Changes in and prognostic value of the inflammatory index before and after concurrent chemoradiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 36-41.
[9] This study was aimed at determining vestibular involvement and the location and frequency of vestibular dysfunction in patients with auditory neuropathy. MethodsTwenty patients with non-syndromic auditory neuropathy were enrolled. Using vestibular test battery, we calculated the ocular vestibular-evoked myogenic potential(oVEMP), cervical vestibular-evoked myogenic potential(cVEMP), video head impulse test(vHIT), suppression head impulse paradigm(SHIMP), and caloric test results. ResultsThe oVEMP and cVEMP were calculated for all patients, and the abnormality rates were % and %, respectively, showing no significant difference. The vHIT in the lateral, anterior, and posterior semicircular canals, and SHIMP in the lateral canals were calculated for patients( ears), and the abnormality rates were %, %, %, and %, respectively, showing no significant difference among the four tests. Nineteen patients exhibited a % abnormality rate for the caloric test. Of the patients with the SHIMP and vHIT results, % showed abnormal caloric test results, which was much higher than the abnormality rate of SHIMP and vHIT. ConclusionPatients with auditory neuropathy showed vestibular involvement, and the superior and inferior vestibular components, including the vestibular peripheral receptors and nerves, had an equal probability of dysfunction. All the otolith organs and semicircular canals could be involved. The possibility of dysfunction was equal for different portions of the semicircular canal, while the functional involvement was more likely to be observed in low-frequency tests.. Location and frequency characteristics of vestibular dysfunction in patients with nonsyndromic auditory neuropathy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 39-45.
[10] ZHANG Jianli, CHEN Weixiong, CHEN Ruikai, KUANG Debing, PANG Yishi. Evaluation of the effect of fiberoptic endoscopic evaluation of swallowing on long-term survivor with nasopharyngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 56-59.
[11] Ling ZHANG,Haibo YE,Haibo SHI. A new mechanism of bilirubin-induced auditory nervous system injury [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 31-35.
[12] Pengli LIU,Lu ZHANG,Xiaolu LI. Differential expression of synaptic vesicle glycoprotein 2A in central auditory system of rats [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 56-60.
[13] Yan JIANG. Recurrence of nasopharyngeal carcinoma and application of endoscopic surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 1-11.
[14] Dongping CHEN,Zhihuan YANG,Yan ZHANG,Nan FANG,Bin QI. Status of surgical treatment for recurrent nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 12-16.
[15] Qianhui QIU,Zhuo CHEN. Endoscopic surgery for the treatment of locally advanced nasopharyngeal carcinoma and serious complications after radiotherapy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 17-20.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(2): 116 -118 .
[2] ZHOU Zi-ning,JIN Guo-wei . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 462 -465 .
[3] ZHOU Bin,LI Bin . Endoscopic sinus surgery for 75 patients with chronic sinusitis and nasal polyps[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 24 -26 .
[4] XU Sainan,YANG Lei . Apoptosis of epithelial cells in nasal polyps promoted by erythromycin[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 27 -29 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 94 -95 .
[6] LIU Lian-he . Treatment of deep neck abscess in 37 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 180 -181 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 200 -203 .
[8] QIAO Yi,NI Guan-sen,CHEN Wen-wen . Effect of H-UPPP and nasal operations on obstructive sleep apnea syndrome in 38 cases
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 206 -208 .
[9] WANG Xiao-feng,LIN Chang,CHENG Jin-mei . Expression of ABAD in inner ears and its clinical significance in different age mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 207 -211 .
[10] FAN Qi-jun,HUANG Zhi-wu,MEI Ling,XIAO Bo-kui . Expression of the heat shock protein 27 in rat cochlea induced by sodium salicylate injection by the FQ-PCR technique[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 212 -214 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd