Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 142-146.doi: 10.6040/j.issn.1673-3770.0.2021.584

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Research progress on NLRP3 inflammasome in chronic rhinosinusitis and allergic rhinitis

LIU Yitong1,2, ZHOU Suizi1,2Overview,QIU Qianhui2   

  1. 1. The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510280, Guangdong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China
  • Published:2022-06-15

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Abstract: Chronic rhinosinusitis(CRS)and allergic rhinitis(AR)are common upper airway inflammatory diseases. CRS and AR pathogenesis may be related to the overactivation of inflammasomes containing nucleotide-binding oligomerization domain-like receptor family(NLRs). NLR protein 3(NLRP3)is the most clinically important inflammasome in the NLR family. The reported frequency of NLRP3 has increased in recent years. This review summarizes the influence of NLPR3 on CRS and AR from three aspects: pathogenesis, disease progression, and disease treatment. Our goal is to provide a deeper understanding of the occurrence and development of these diseases and provide references for exploring various therapeutic targets.

Key words: Chronic rhinosinusitis, Allergic rhinitis, NLRP3 inflammasome, Nod-like receptors

CLC Number: 

  • R765.4+1
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