Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (4): 30-37.doi: 10.6040/j.issn.1673-3770.0.2023.210

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A randomized controlled clinical trial of sound therapy combined with medication in the treatment of chronic subjective tinnitus

DONG Hongsong, WANG Chunli, YU Yanping, CHEN Tao, NIE Guohui   

  1. Department of Otolaryngology Head and Neck Surgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, Guangdong, China
  • Published:2023-07-27

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Abstract: Objective To investigate the short-term efficacy and difference between sound therapy combined with medication and medication alone in patients with chronic subjective tinnitus. Methods A total of 64 patients with chronic tinnitus(> 6 months)were included in the study. Using a randomized controlled method, patients were divided into two groups(n=32 each): combined sound and drug(combined treatment); and drug alone. Based on tinnitus counseling, the drug group was administered oral ginkgo biloba extract tablet, while the combined group was administered personalized multiple compound sound therapy based on drug therapy. The Tinnitus Handicap Inventory(THI), visual analog scale(VAS), and Self-rating Anxiety Scale(SAS)scores were compared between the two groups before and after 1 month of treatment. The effectiveness rate of tinnitus treatment was compared between the two groups and possible factors affecting treatment efficacy were analyzed. Results THI, VAS, and SAS scores in the drug and combined groups were decreased after treatment(P<0.05). Differences in THI and VAS scores in the combination treatment group were greater than those in the drug group before and after treatment(P<0.05). There was no statistical difference in SAS score between the two groups before and after short-term treatment. The total treatment effectiveness rate in the combined treatment group was higher than that of the drug group(P<0.05). Sex, age, tinnitus frequency, tinnitus side, tinnitus tone, and hearing loss frequency band were not significantly correlated with tinnitus treatment efficacy(P>0.05). Conclusion Based on tinnitus consultation, both sound therapy combined with medication and drug alone have certain efficacy in the treatment of tinnitus. Compared with drug alone, however, combined treatment more effectively alleviated subjective severity of the impact of tinnitus on patient life, and yielded a higher total effectiveness rate. Sex, age, tinnitus frequency, tinnitus side, tinnitus tone, and hearing loss frequency band matching and other factors did not exert significant influence on the efficacy of tinnitus treatment.

Key words: Chronic subjective tinnitus, Sound Therapy, Medicine, Multiple Compound Sound Therapy, Gingko Biloba Leaves

CLC Number: 

  • R764.45
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