Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (1): 138-142.doi: 10.6040/j.issn.1673-3770.0.2022.531

• Review • Previous Articles    

Application of optical coherence tomography in idiopathic epiretinal membrane

LIU Jiangchuan1, LI Pengwei1, GUO Jianqiang2, LU Huiqin2   

  1. 1. Department of Ophthalmology, Huanghe Sanmenxia Hospital, Sanmenxia 472000, Henan, China 2. Department of Ophthalmology, Xi'an NO.1 Hospital, Xi'an 710002, Shaanxi, China
  • Published:2024-01-12

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Abstract: Idiopathic epiretinal membrane(iERM)is a medically unexplained ophthalmic disease that can cause a decline in vision quality due to complex and diverse changes in the retina through continuous vitreomacular traction. Optical coherence tomography(OCT)can clearly display the characteristic changes to the retina caused by iERM. In the inner retina, different forms of iERM can produce different visual prognoses. For example, the appearance of ectopic inner foveal layers is a risk factor for vision loss, thickening of the inner nuclear layer can cause visual distortion, and intraretinal cystic spaces may be related to injured Müller cells. In the outer retina, the integrity of the ellipsoid zone, interdigitation zone, and the cotton ball sign can indicate the degree of photoreceptor damage. This article reviews the characteristic changes visible on OCT in patients with iERM.

Key words: Idiopathic epiretinal membrane, Optical coherence tomography, Ellipsoid zone, Ectopic inner foveal layers

CLC Number: 

  • R774.5
[1] Chua PY, Sandinha MT, Steel DH. Idiopathic epiretinal membrane: progression and timing of surgery[J]. Eye(Lond), 2022, 36(3): 495-503. doi:10.1038/s41433-021-01681-0
[2] Duker JS, Kaiser PK, Binder S, et al. The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole[J]. Ophthalmology, 2013, 120(12): 2611-2619. doi:10.1016/j.ophtha.2013.07.042
[3] Fung AT, Galvin J, Tran T. Epiretinal membrane: a review[J]. Clin Exp Ophthalmol, 2021, 49(3): 289-308. doi:10.1111/ceo.13914
[4] Byon IS, Pak GY, Kwon HJ, et al. Natural history of idiopathic epiretinal membrane in eyes with good vision assessed by spectral-domain optical coherence tomography[J]. Ophthalmologica, 2015, 234(2): 91-100. doi:10.1159/000437058
[5] 林晓芹, 吴苗琴. 特发性视网膜前膜的发病机制及治疗进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 121-128. doi:10.6040/j.issn.1673-3770.0.2019.499 LIN Xiaoqin, WU Miaoqin. Pathogenesis and treatment of idiopathic epiretinal membranes[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 121-128. doi:10.6040/j.issn.1673-3770.0.2019.499
[6] Konidaris V, Androudi S, Alexandridis A, et al. Optical coherence tomography-guided classification of epiretinal membranes[J]. Int Ophthalmol, 2015, 35(4): 495-501. doi:10.1007/s10792-014-9975-z
[7] Taniguchi H, Yoshida I, Sakamoto M, et al. Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration[J]. BMC Ophthalmol, 2021, 21(1): 190. doi:10.1186/s12886-021-01944-0
[8] Govetto A, Lalane RA, Sarraf D, et al. Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme[J]. Am J Ophthalmol, 2017, 175: 99-113. doi:10.1016/j.ajo.2016.12.006
[9] González-Saldivar G, Berger A, Wong D, et al. Ectopic inner foveal layer classification scheme predicts visual outcomes after epiretinal membrane surgery[J]. Retina, 2020, 40(4): 710-717. doi:10.1097/IAE.0000000000002486
[10] Govetto A, Virgili G, Rodriguez FJ, et al. Functional and anatomical significance of the ectopic inner foveal layers in eyes with idiopathic epiretinal membranes: surgical results at 12 months[J]. Retina, 2019, 39(2): 347-357. doi:10.1097/IAE.0000000000001940
[11] Doguizi S, Sekeroglu MA, Ozkoyuncu D, et al. Clinical significance of ectopic inner foveal layers in patients with idiopathic epiretinal membranes[J]. Eye(Lond), 2018, 32(10): 1652-1660. doi:10.1038/s41433-018-0153-9
[12] Govetto A, Su D, Farajzadeh M, et al. Microcystoid macular changes in association with idiopathic epiretinal membranes in eyes with and without Glaucoma: clinical insights[J]. Am J Ophthalmol, 2017, 181: 156-165. doi:10.1016/j.ajo.2017.06.023
[13] Baek J, Park HY, Lee JH, et al. Elevated M2 macrophage markers in epiretinal membranes with ectopic inner foveal layers[J]. Invest Ophthalmol Vis Sci, 2020, 61(2): 19. doi:10.1167/iovs.61.2.19
[14] Bressler NM, Edwards AR, Antoszyk AN, et al. Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy[J]. Am J Ophthalmol, 2008, 145(5): 894-901. doi:10.1016/j.ajo.2007.12.025
[15] Chalam KV, Bressler SB, Edwards AR, et al. Retinal thickness in people with diabetes and minimal or no diabetic retinopathy: Heidelberg Spectralis optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(13): 8154-8161. doi:10.1167/iovs.12-10290
[16] Kang HM, Koh HJ, Lee SC. Visual outcome and prognostic factors after surgery for a secondary epiretinal membrane associated with branch retinal vein occlusion[J]. Graefes Arch Clin Exp Ophthalmol, 2015, 253(4): 543-550. doi:10.1007/s00417-014-2731-2
[17] Okamoto F, Sugiura Y, Okamoto Y, et al. Inner nuclear layer thickness as a prognostic factor for Metamorphopsia after epiretinal membrane surgery[J]. Retina, 2015, 35(10): 2107-2114. doi:10.1097/iae.0000000000000602
[18] Ichikawa Y, Imamura Y, Ishida M. Inner nuclear layer thickness, a biomarker of Metamorphopsia in epiretinal membrane, correlates with tangential retinal displacement[J]. Am J Ophthalmol, 2018, 193: 20-27. doi:10.1016/j.ajo.2018.06.001
[19] Labin AM, Safuri SK, Ribak EN, et al. Müller cells separate between wavelengths to improve day vision with minimal effect upon night vision[J]. Nat Commun, 2014, 5: 4319. doi:10.1038/ncomms5319
[20] 李鹏伟, 苏光明, 刘江川, 等. 光学相干断层扫描血管成像在2型黄斑毛细血管扩张症中的应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 140-144. doi: 10.6040/j.issn.1673-3770.0.2021.45 LI Pengwei, SU Guangming, LIU Jiangchuan, et al. Application of optical coherence tomography angiography in macular telangiectasia type 2[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 140-144. doi: 10.6040/j.issn.1673-3770.0.2021.45
[21] Shiode Y, Morizane Y, Toshima S, et al. Surgical outcome of idiopathic epiretinal membranes with intraretinal cystic spaces[J]. PLoS One, 2016, 11(12): e0168555. doi:10.1371/journal.pone.0168555
[22] Güler M, Urfalıo glu S, Damar Güngör E, et al. Clinical and optical coherence tomography analysis of intraretinal microcysts in patients with epiretinal membrane[J]. Semin Ophthalmol, 2021, 36(8): 787-793. doi:10.1080/08820538.2021.1906915
[23] Cobos E, Arias L, Ruiz-Moreno J, et al. Preoperative study of the inner segment/outer segment junction of photoreceptors by spectral-domain optical coherence tomography as a prognostic factor in patients with epiretinal membranes[J]. Clin Ophthalmol, 2013, 7: 1467-1470. doi:10.2147/OPTH.S44837
[24] Spaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model[J]. Retina, 2011, 31(8): 1609-1619. doi:10.1097/IAE.0b013e3182247535
[25] Fernández EJ, Hermann B, Povazay B, et al. Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina[J]. Opt Express, 2008, 16(15): 11083-11094. doi:10.1364/oe.16.011083
[26] Shimozono M, Oishi A, Hata M, et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery[J]. Am J Ophthalmol, 2012, 153(4): 698-704.e1. doi:10.1016/j.ajo.2011.09.011
[27] Watanabe K, Tsunoda K, Mizuno Y, et al. Outer retinal morphology and visual function in patients with idiopathic epiretinal membrane[J]. JAMA Ophthalmol, 2013, 131(2): 172-177. doi:10.1001/jamaophthalmol.2013.686
[28] Stevenson W, Prospero Ponce CM, Agarwal DR, et al. Epiretinal membrane: optical coherence tomography-based diagnosis and classification[J]. Clin Ophthalmol, 2016, 10: 527-534. doi:10.2147/OPTH.S97722
[29] Fernandes TF, Sousa K, Azevedo I, et al. Baseline visual acuity and interdigitation zone as predictors in idiopathic epiretinal membranes: a retrospective cohort study[J]. Eur J Ophthalmol, 2021, 31(3): 1291-1298. doi:10.1177/1120672120932094
[30] Li DQ, Rudkin AK, Altomare F, et al. Predicting progression of untreated macular pucker using retinal surface en face optical coherence tomography[J]. Ophthalmologica, 2020, 243(5): 323-333. doi:10.1159/000497490
[31] Tsunoda K, Watanabe K, Akiyama K, et al. Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane[J]. Ophthalmology, 2012, 119(3): 581-587. doi:10.1016/j.ophtha.2011.08.026
[32] Govetto A, Bhavsar KV, Virgili G, et al. Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives[J]. Am J Ophthalmol, 2017, 184: 167-180. doi:10.1016/j.ajo.2017.10.011
[33] Brinkmann MP, Michels S, Brinkmann C, et al. Epiretinal membrane surgery outcome in eyes with abnormalities of the central bouquet[J]. Int J Retina Vitreous, 2021, 7(1): 7. doi:10.1186/s40942-020-00279-0
[34] Spaide RF. Closure of an outer lamellar macular hole by vitrectomy: hypothesis for one mechanism of macular hole formation[J]. Retina, 2000, 20(6): 587-590. doi:10.1097/00006982-200006000-00001
[35] Bringmann A, Unterlauft JD, Wiedemann R, et al. Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study[J]. Int Ophthalmol, 2020, 40(11): 2931-2948. doi:10.1007/s10792-020-01477-3
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