Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (1): 54-60.doi: 10.6040/j.issn.1673-3770.0.2023.309

• Original Article • Previous Articles    

Study on correlation between traditional Chinese medicine syndrome types and TFH cell related factors in CRSwNP

WANG Aowei1, SHI Wenjie2   

  1. 1. Graduate Shool of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China2. Department of Otorhinolaryngology & Head and Neck Surgery Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan, China
  • Published:2025-01-17

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Abstract: Objective To explore the relationship between immunoglobulin E(IgE), follicular helper T-cell(TFH)related factor interleukin-21(IL-21), and traditional Chinese medicine syndrome types of chronic rhinosinusitis with nasal polyps(CRSwNP). Methods A retrospective study was conducted on 58 patients with CRSwNP who underwent endoscopic sinus surgery were divided into a cold dampness condensation syndrome group and a dampness heat accumulation syndrome group. General information, total serum igand traditional Chinese medicine diagnostic data were collected; collect nasal polyp tissue samples during surgery, and use enzyme-linked immunosorbent assay to detect IgE and IL-21 in the patient's nasal polyp tissue. Use immunohistochemistry to detect the positive expression of Bcl-6 in the patient's nasal polyp tissue. Using relevant statistical methods, explore the correlation between the expression of TFH cells and related factors and the types of traditional Chinese medicine syndromes. Results There was no statistically significant difference in the levels of IgE, IL-21, and Bcl-6 in nasal polyp tissue between the two traditional Chinese medicine syndrome types(all P>0.05); There is a positive correlation between Bcl-6 expression and IgE levels in nasal polyps of patients with cold dampness condensation syndrome(r=0.491, P=0.024), There is no correlation between IgE levels and Bcl-6 expression in nasal polyps of patients with dampness heat accumulation syndrome(P=0.195); The total serum IgE levels in patients with cold dampness aggregation syndrome were significantly higher than those in patients with dampness heat accumulation syndrome(P=0.013). Conclusion The expression of IgE, IL-21, and Bcl-6 in nasal polyps is not related to traditional Chinese medicine syndrome types, while serum IgE is related to traditional Chinese medicine syndrome types. In the cold dampness accumulation syndrome group, the effect of Bcl-6 on IgE in nasal polyp tissue is greater than that in the heat dampness accumulation syndrome group.

Key words: Chronic rhinosinusitis, Nasal polyps, Follicular helper T cell, Traditional Chinese medicine syndrome types

CLC Number: 

  • R765.4
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