Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 156-161.doi: 10.6040/j.issn.1673-3770.0.2022.258

• Review • Previous Articles    

Research progress on the role of TH2 cytokines in Type2 chronic rhinosinusitis with nasal polyps

ZHU Yu, ZHU Xinhua   

  1. Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
  • Published:2023-10-13

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Abstract: Chronic rhinosinusitis(CRS)are classified as type 2 and non-type 2 intrainflammatory types according to the pathogenesis, where type 2 inflammation corresponds to chronic rhinosinusitis with nasal polyps(CRSwNP)dominated by eosinophil infiltration. Patients with typical type 2 CRSwNP are typically resistant to current treatments and exhibit high recurrence rates. Although some success has been achieved regarding treatment, targeting a single TH2 cytokine cannot completely eliminate type 2 CRSwNP in most patients. Therefore, targeting the TH2 cytokine and its downstream signal transduction pathway may present a novel approach for endotherapy. In this study, we review the intracellular signaling pathways activated by various type 2 cytokines(IL-4, IL-5, IL-9, IL-13, IL-25, and IL-33)after binding to their specific receptors in type 2 CRSwNP, in order to provide new targets for type 2 CRSwNP therapeutics.

Key words: Chronic rhinosinusitis, Nasal polyps, TH2 cytokines, Eosinophil, Signal transduction pathway

CLC Number: 

  • R765.4+1
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