Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (2): 79-86.doi: 10.6040/j.issn.1673-3770.0.2024.369

• Original Article • Previous Articles     Next Articles

Clinicopathologic and survival analysis of laryngeal neuroendocrine neoplasm in 26 cases

XIE Feng1, XU Zhenju1, WU Ce1, LIU Jie1, ZANG Chuanshan1, ZHANG Longxiao2, HAN Min1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery;
    2. Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Published:2025-03-26

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Abstract: Objective The objective of this study was to investigate the clinicopathologic characteristics of laryngeal neuroendocrine neoplasm and to conduct a survival analysis, with the aim of providing a valuable reference for clinical diagnosis and treatment. Methods A retrospective study of clinical data was conducted for a total of 26 patients diagnosed laryngeal neuroendocrine neoplasm. The clinical data was then grouped for the purpose of comparison. Survival analysis was perfoemed using both Kaplan-Meier analysis and Cox proportional-hazards regression models. Results Laryngeal neuroendocrine neoplasm(LNN)was most prevalent in the well-differentiated cases, and significant disparities were observed between the two groups with respect to the body mass index(BMI), tumour size, and Ki-67 labeling index. The 5-year overall survival rate for LNN was 43.2%, signifying a poor prognosis. Multifactorial analysis showed that lymph node metastasis, high Ki-67 labeling index and distant metastasis were independent risk factors affecting patients' overall survival rate. Conclusion Laryngeal neuroendocrine neoplasms manifesting diverse differentiation patterns exhibit distinct characteristics. The most significant factors affecting the overall survival rate are the Ki-67 labeling index, the presence of distant metastasis, and lymph node metastasis.

Key words: Laryngeal cancer, Neuroendocrine neoplasm, Survival analysis, Ki-67

CLC Number: 

  • R739.65
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