Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 50-53.doi: 10.6040/j.issn.1673-3770.0.2022.433

• Original Article • Previous Articles     Next Articles

Diagnostic utility of folate receptor-positive circulating tumor cells in patients with laryngeal squamous cell carcinoma

ZHANG Zhuping, YE Qi, GUO Bei, LIN Ling   

  1. Department of Otolaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei, China
  • Published:2023-10-13

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Abstract: Objective To determine serum levels of folate receptor-positive circulating tumor cells(FR+-CTCs)in patients with laryngeal squamous cell carcinoma(LSCC)and investigate its utility in the diagnosis of LSCC. Methods Forty-two patients with LSCC and 22 with benign laryngeal lesions admitted to the authors’ hospital were enrolled in this study. The significance of peripheral blood levels of FR+-CTCs, combined with clinical characteristics, in the diagnosis of LSCC was analyzed. Results FR+-CTC levels in patients with LSCC were higher than those in the benign group(t=7.269, P<0.001). Additionally, FR+-CTC level was associated with clinical stage, T stage, and differentiation grade(P<0.05), but not with sex, age, location, smoking, or lymph node metastasis(P>0.05). The area under the receiver operating characteristic curve was 0.857; sensitivity was 76.2% and specificity was 95.5% for the detection of LSCC with 9.0 FU/3 mL as the cut-off value. Conclusion Peripheral blood levels of FR+-CTCs in patients with LSCC were increased and was associated with clinical stage and differentiation grade. The determination of FR+-CTC levels is anticipated to be applied in the clinical diagnosis of LSCC.

Key words: Laryngeal cancer, Folate receptor, Circulating tumor cell, Serum, Biomarkers

CLC Number: 

  • R739.6
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