盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

山东大学耳鼻喉眼学报

盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察

薛卫国，孙洁，金铮，石文斌，辛露，林国经，李加耘

1. 青岛市立医院耳鼻咽喉-头颈外科，山东青岛 266011；2. 青岛市立医院药剂科, 山东青岛 266011；3. 福建医科大学附属协和医院耳鼻咽喉-头颈外科, 福建福州 350000；4. 陕西省人民医院耳鼻咽喉-头颈外科, 陕西西安 710000

收稿日期:2006-03-29 修回日期:1900-01-01 出版日期:2006-08-24 发布日期:2006-08-24
通讯作者: 薛卫国

XUE Wei-guo,SUN Jie,JIN Zheng，SHI Wen-bin,XIN Lu,LIN Guo-Jing, LI Jia-yun

1. Department of Otolaryngology ＆ Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China; 2. Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011,

Received:2006-03-29 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
Contact: XUE Wei-guo

摘要/Abstract

摘要： 目的：评价盐酸左氧氟沙星滴耳液治疗中耳炎的有效性和安全性。方法：采用同类有效药物氧氟沙星滴耳液作为对照，进行随机、双盲、阳性药物平行对照、多中心临床试验。结果：完成试验方案的可供疗效分析的患者120例,试验组和对照组各60例。试验组有效率为96.67%，细菌清除率为96.15%；对照组分别为85.00%和95.83%，两组差异无统计学意义(P均＞0.05)。结论：盐酸左氧氟沙星滴耳液治疗中耳炎疗效显著，细菌清除率高，安全性好，与氧氟沙星滴耳液疗效相近。

关键词: 中耳炎, 左氧氟沙星, 氧氟沙星, 治疗结果

Abstract: To observe the efficacy and safety of the levofloxacin ear drop in the treatment of otitis media. Method: A randomized, doubleblind, multicenter, ofloxacin ear drop controlled trial was performed. Results: The data of 120 patients were analyzed, and 60 patients were in the group of levofloxacin ear drop and the other 60 in the group of ofloxacin ear drop. Efficacy assessment based on symptom score reducing index showed that the efficacy rate of levofloxacin ear drop was 96.67% and that of the ofloxacin ear drop was 85.00%; the eradication rate of pathogens in the group of levofloxacin ear drop was 96.15% and in the group of ofloxacin ear drop was 95.83%. No significant difference was showed between two groups (both P＜0.05). Conclusions: Levofloxacin ear drop is effective and safe in treating otitis media. The efficacy of levofloxacin ear drop is similar to that of ofloxacin ear drop.

Key words: Levofloxacin, Otitis media, Ofloxacin, Treatment outcome

薛卫国,孙洁,金铮,石文斌,辛露,林国经,李加耘 . 盐酸左氧氟沙星滴耳液治疗中耳炎的疗效观察[J]. 山东大学耳鼻喉眼学报, 2006, 20(4): 300-303 .

XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(4): 300-303 .

参考文献

相关文章 15

[1]	张国民,王茂华,高松,吴文斌,虞幼军. 持续灌流模式耳内镜下粘连性中耳炎手术疗效分析[J]. 山东大学耳鼻喉眼学报, 2026, 40(3): 16-19.
[2]	宋瑾,尹慧,高娴,李永团. 坏死梭杆菌致成人中耳炎并发脑膜炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 96-100.
[3]	周莹,王刚,王磊,张晓丽,韩浩伦,李保卫,孙喆喆,吴玮. 咽喉反流相关中耳炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 131-135.
[4]	樊永将,黄卫,何成山,沈海涛,徐正,郝亚楠. SARS-CoV-2感染后成人急性分泌性中耳炎细胞因子水平分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 1-6.
[5]	钟佳珂,王柏杨,伊海金. 以耳部症状首发、合并鼻咽占位的肉芽肿性多血管炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 6-14.
[6]	孙艳,姚浩,顾黎安. 布地奈德联合盐酸氨溴索鼓室内注射治疗成人分泌性中耳炎的疗效研究[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 77-82.
[7]	高信忠, 林宗通, 沈翎, 刘平凡, 林兴, 许杨杨. 咽鼓管球囊扩张联合腺样体切除术治疗儿童分泌性中耳炎疗效分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 7-12.
[8]	焦雪梅,杨扬,李春凤,张晓琳. 鼓膜置管对分泌性中耳炎患儿咽鼓管功能的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 60-63.
[9]	吴华,孙永明,郑建华,蔡雪花. 腺样体消融联合鼓膜打孔术治疗儿童腺样体肥大合并分泌性中耳炎55例[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 71-75.
[10]	王海霞,张彩霞,李银银,郑金秀,陈曦. 经鼓室注射内耳钆造影显影不良原因初探[J]. 山东大学耳鼻喉眼学报, 2020, 34(5): 61-66.
[11]	魏馨雨,杨方园,杨军,张青. 耳源性细菌性迷路炎研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(5): 102-107.
[12]	林宗通,沈翎,杨中婕. 腺样体大小及圆枕类型对儿童分泌性中耳炎的影响[J]. 山东大学耳鼻喉眼学报, 2020, 34(5): 121-126.
[13]	许玲, 孙岩. 三叶因子家族在中耳呼吸型黏膜上皮的研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(1): 93-98.
[14]	曹鑫,伊海金,李欣,许嘉,高娟娟. 分泌性中耳炎合并突发性聋三例并文献复习[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 56-61.
[15]	倪菁,雷飞,白丹,周韵,马建梅,黄伟,王春阳. 儿童分泌性中耳炎耳积液中免疫相关指标表达分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 56-59.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed