miRNA在头颈肿瘤的应用进展

doi:10.6040/j.issn.1673-3770.0.2015.170

山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 79-82.doi: 10.6040/j.issn.1673-3770.0.2015.170

miRNA在头颈肿瘤的应用进展

周娟, 郑家法

南华大学附属南华医院耳鼻咽喉科, 湖南衡阳 421001

收稿日期:2015-04-24 修回日期:2015-09-22 出版日期:2015-10-16 发布日期:2015-10-16
通讯作者: 郑家法,E-mail:13975466338@139.com E-mail:13975466338@139.com
作者简介:周娟,E-mail:1075765033@qq.com

Research progress of miRNA in head and neck cancers

ZHOU Juan, ZHENG Jiafa

Department of Otorhinolaryngology Head and Neck Surgery, Nanhua Hospital Affiliated to University of South China, Hengyang 421001, Hunan, China

Received:2015-04-24 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

摘要/Abstract

摘要： microRNA又称miRNA,是一类非编码的单链小分子RNA,通过与靶mRNA的3'UTR(3'末端非翻译区)不完全或完全互补配对调节基因的表达,在肿瘤的发生、发展中扮演着重要角色。本文就miRNA在头颈肿瘤的诊断、预后、治疗等方面作一综述。

关键词: miRNA, 头颈肿瘤, 基因

Abstract: A microRNA, abbreviated miRNA, is a non-coding single-stranded small molecular RNA. Through incomplete or complete complementary pairing with target mRNA 3' UTR (3' end untranslated region), it plays an important role in the occurrence and development of tumors. This paper reviews the role of miRNA in the diagnosis, prognosis and treatment of head and neck cancers.

Key words: Head and neck cancers, miRNA, Gene

中图分类号:

R739.91

周娟, 郑家法. miRNA在头颈肿瘤的应用进展[J]. 山东大学耳鼻喉眼学报, 2015, 29(5): 79-82.

ZHOU Juan, ZHENG Jiafa. Research progress of miRNA in head and neck cancers[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 79-82.

参考文献

[1] Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009, 45(4-5): 309-316.
[2] Nagadia R, Pandit P, Coman W B, et al. miRNAs in head and neck cancer revisited[J]. Cell Oncol (Dordr), 2013, 36(1): 1-7.
[3] Warnakulasuriya S. Causes of oral cancer—an appraisal of controversies[J]. Br Dent J, 2009, 207(10): 471-475.
[4] Lee R C, Feinbaum R L, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5): 843-854.
[5] Malumbres M. miRNAs and cancer: an epigenetics view[J]. Mol Aspects Med, 2012, 34: 863-874.
[6] Li J, Huang H, Sun L, et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor[J]. Clin Cancer Res, 2009, 15(12): 3998-4008.
[7] Yu Z W, Zhong L P, Ji T, et al. MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines[J]. Oral Oncol, 2010, 46(4): 317-322.
[8] Kozaki K, Imoto I, Mogi S, et al. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer[J]. Cancer Res, 2008, 68(7): 2094-2105.
[9] Avissar M, Christensen B C, Kelsey K T, et al. MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma[J]. Clin Cancer Res, 2009, 15(8): 2850-2855.
[10] 张春妮, 张辰宇. 体液microRNA作为新的无创伤性生物标志物的意义[J]. 分子诊断与治疗杂志, 2011, 3(3): 145-151. ZHANG Chunni, ZHANG Chenyu. The significance of humoral microRNA as a new biomarker for noninvasive biological[J]. J Mole Diagn Ther, 2011, 3(3): 145-151.
[11] 孙伟, 史冬泉, 蒋青. 血清microRNA的检测及临床应用进展[J]. 医学综述, 2011, 17(23): 3616-3618. SUN Wei, SHI Dongquan, JIANG Qing. Progress of detection and clinical application of serum microRNA[J]. Med Survey, 2011, 17(23): 3616-3618.
[12] Liu C J, Kao S Y, Tu H F, et al. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer[J]. Oral Dis, 2010, 16(4): 360-364.
[13] Park N J, Zhou H D, Elashoff D, et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection[J]. Clin Cancer Res, 2009, 15(17): 5473-5477.
[14] Siow M Y, Karen Ng L P, Vincent Chong V K, et al. Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma[J]. Oral Dis, 2014, 20(4): 345-351.
[15] Rather M I, Nagashri M N, Swamy S S, et al. Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics[J]. J Biol Chem, 2013, 288(1): 608-618.
[16] Su J, Baigude H, McCarroll J, et al. Silencing microRNA by interfering nanoparticles in mice[J]. Nucleic Acids Res, 2011, 39(6): 38.
[17] 陈建, 王朝霞. 微小RNA: 肿瘤耐药治疗新靶点[J]. 现代肿瘤医学, 2012, 20(01): 191-196. CHEN Jian, WANG Zhaoxia. miRNA: Tumor drug resistance therapy target[J]. Mod Tumor Med, 2012, 20(1): 191-196.

相关文章 15

[1]	王敏,刘皓,姜露涵,谭立约,李文,付小龙. AAV-ie-Tnfaip8l2的包装及其对Tnfaip8l2^-/-小鼠听觉功能的改善效果[J]. 山东大学耳鼻喉眼学报, 2026, 40(3): 7-15.
[2]	盘琳琳,万佳明,李越,何龙. 自噬相关LncRNA是头颈部鳞状细胞癌的预后指标[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 97-107.
[3]	李洁,苏维娜,林倩,张奇舒,侯成,杨振娇,相丽丽. 两例耳聋病例中MARVELD2基因变异的遗传学分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 128-134.
[4]	窦涛,窦乃馨,汪如,杨芊,管庆波,王磊,于春晓. miRNA-mRNA网络参与高脂饮食损伤甲状腺功能的生物信息学分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 151-160.
[5]	张丽霞,李琳. 基于GEO数据库筛选年龄相关性听力损失关键基因的分析研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 104-114.
[6]	王博深,冷辉,孙海波. 梅尼埃病与前庭性偏头痛共表达基因特征及天麻素的分子对接预测[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 29-40.
[7]	王玲,黎明,应方微,王玉,温文,姚晓明. 微孢子虫感染导致角膜穿孔1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 95-99.
[8]	倪荣生,沈晓辉,高下. 基质金属蛋白酶及其抑制剂在喉鳞癌中的基因表达谱及临床病理特征相关性分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 55-61.
[9]	刘若武,张晗. Leber遗传性视神经病变的基因治疗进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 154-158.
[10]	艾朝晖, 张杰. 色素失禁症相关性眼病诊疗研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 166-174.
[11]	卢松,夏逸帆,李子晔,魏菁. 无视网膜脱离的儿童Stickler综合征1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 97-101.
[12]	张瑾,亓志玲,王少华,赵玉凤,马旭,吴允刚. 神经纤维瘤病Ⅰ型新致病基因突变1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 73-78.
[13]	李为,赵毅,葛玥铭,付洪涛,王进东,张晓龙,董洁,程钰翔. 新生儿常见耳聋基因突变热点及对听力的影响[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 1-8.
[14]	张永红,张辉,王彩华,杨欣欣,吴允刚,赵玉凤,庞太忠,李晓瑜. 基于TCGA数据库构建喉鳞状细胞癌免疫相关基因预后模型及筛选靶向分子药物[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 54-62.
[15]	周一静,邹建银,易红良,吴红敏. TGFBI在头颈部鳞状细胞癌中的表达及其临床意义[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 85-95.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

miRNA在头颈肿瘤的应用进展

Research progress of miRNA in head and neck cancers

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

多维度评价

本文评价

推荐阅读 0