山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (5): 132-136.doi: 10.6040/j.issn.1673-3770.0.2020.539

• • 上一篇    

运用OCT及OCTA观察硅油对视网膜脉络膜的影响

张昕雨,雷春燕,张美霞   

  1. 四川大学华西医院 眼科, 四川 成都 610041
  • 发布日期:2021-09-29
  • 通讯作者: 张美霞. E-mail:zhangmeixia@scu.edu.cn

Retinochoriodal changes associated with silicone oil tamponade detected by optical coherence tomography and optical coherence tomography angiography

ZHANG Xinyu,LEI Chunyan, ZHANG Meixia   

  1. Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China
  • Published:2021-09-29

摘要: 硅油作为一种玻璃体替代物被广泛应用于复杂性玻璃体视网膜疾病的手术治疗中。虽然硅油的安全性和有效性已被广泛认可,但其在眼内的填充仍可引起眼前段及眼后段的多种并发症。近年来,随着光学相干断层扫描(OCT)及光学相干断层扫描血管成像(OCTA)的出现和应用,有关硅油填充对视网膜脉络膜影响的研究更为深入。论文主要就运用OCT及OCTA观察硅油填充术后视网膜脉络膜血流及结构的改变进行综述。

关键词: 硅油类, 光学相干断层扫描, 光学相干断层扫描血管成像, 视网膜, 脉络膜

Abstract: Silicone oil, as a vitreous substitute, is widely applied to the surgical treatment of complicated vitreoretinal diseases. Although silicone oil is generally recognized for its safety and efficacy, its intraocular tamponade can cause various complications in the anterior and posterior segments of the eyes. With the emergence and application of Optical Coherence Tomography(OCT)and Optical Coherence Tomography Angiography(OCTA)in recent years, retinochoroidal changes associated with silicone oil tamponade have been further studied. This review summarizes the changes in the blood flow and structure of the retina and choroid associated with silicone oil tamponade, which were detected by OCT and OCTA.

Key words: Silicone oils, Optical coherence tomography, Optical coherence tomography angiography, Retina, Choroid

中图分类号: 

  • R774.1
[1] Alovisi C, Panico C, de Sanctis U, et al. Vitreous substitutes: old and new materials in vitreoretinal surgery[J]. J Ophthalmol, 2017, 2017: 3172138. doi:10.1155/2017/3172138.
[2] Kleinberg TT, Tzekov RT, Stein L, et al. Vitreous substitutes: a comprehensive review[J]. Surv Ophthalmol, 2011, 56(4): 300-323. doi:10.1016/j.survophthal.2010.09.001.
[3] 段文华, 吴敏. 玻璃体腔填充硅油对视网膜与视神经的影响[J]. 中华眼底病杂志, 2015, 31(6): 614-616. doi:10.3760/cma.j.issn.1005-1015.2015.06.030.
[4] Antoun J, Azar G, Jabbour E, et al. Vitreoretinal surgery with silicone oil tamponade in primary uncomplicated rhegmatogenous retinal detachment: clinical outcomes and complications[J]. Retina,2016, 36(10): 1906-1912. doi:10.1097/iae.0000000000001008.
[5] Tode J, Purtskhvanidze K, Oppermann T, et al. Vision loss under silicone oil tamponade[J]. Graefes Arch Clin Exp Ophthalmol. 2016, 254(8): 1465-1471. doi: 10.1007/s00417-016-3405-z.
[6] Ma Y, Zhu XQ, Peng XY. Macular perfusion changes and ganglion cell complex loss in patients with silicone oil-related visual loss[J]. Biomed Environ Sci, 2020, 33(3): 151-157. doi:10.3967/bes2020.021.
[7] Shalchi Z, Mahroo OA, Shunmugam M, et al. Spectral domain optical coherence tomography findings in long-term silicone oil-related visual loss[J]. Retin Phila Pa, 2015, 35(3): 555-563. doi:10.1097/IAE.0000000000000325.
[8] Siqueira RC, Dos Santos WF, Scott IU, et al. Neuroprotective effects of intravitreal triamcinolone acetonide and dexamethasone implant in rabbit retinas after pars Plana vitrectomy and silicone oil injection[J]. Retina, 2015, 35(2): 364-370. doi:10.1097/iae.0000000000000284.
[9] Cibis PA, Becker B, Okun E, et al. The use of liquid silicone in retinal detachment surgery[J]. Arch Ophthalmol, 1962, 68: 590-599. doi:10.1001/archopht.1962.00960030594005.
[10] Ferrara D, Waheed NK, Duker JS. Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies[J]. Prog Retin Eye Res, 2016, 52: 130-155. doi:10.1016/j.preteyeres.2015.10.002.
[11] Spaide RF, Fujimoto JG, Waheed NK, et al. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64: 1-55. doi:10.1016/j.preteyeres.2017.11.003.
[12] 梁倩倩, 杨庭骅, 赵博军. 光学相干层析血管扫描在视网膜静脉阻塞中的应用[J]. 山东大学耳鼻喉眼学报, 2019, 33(2): 139-142. doi:10.6040/j.issn.1673-3770.0.2018.364. LIANG Qianqian, YANG Tinghua, ZHAO Bojun. Application of optical coherence tomography angiography in retinal vein occlusion[J]. J Otolaryngol Ophthalmol Shandong Univ, 2019, 33(2): 139-142. doi:10.6040/j.issn.1673-3770.0.2018.364.
[13] Gray RH, Cringle SJ, Constable IJ. Fluorescein angiographic findings in three patients with long-term intravitreal liquid silicone[J]. Br J Ophthalmol, 1989, 73(12): 991-995. doi:10.1136/bjo.73.12.991.
[14] Woo JM, Yoon YS, Woo JE, et al. Foveal avascular zone area changes analyzed using OCT angiography after successful rhegmatogenous retinal detachment repair[J]. Curr Eye Res, 2018, 43(5): 674-678. doi:10.1080/02713683.2018.1437922.
[15] Zhou Y, Zhang S, Zhou H, et al. Comparison of fundus changes following silicone oil and sterilized air tamponade for macular-on retinal detachment patients[J]. BMC Ophthalmol, 2020, 20(1): 249. doi:10.1186/s12886-020-01523-9.
[16] Roohipoor R, Tayebi F, Riazi-Esfahani H, et al. Optical coherence tomography angiography changes in macula-off rhegmatogenous retinal detachments repaired with silicone oil[J]. Int Ophthalmol,2020, 40(12): 3295-3302. doi:10.1007/s10792-020-01516-z.
[17] Lee JY, Kim JY, Lee SY, et al. Foveal microvascular structures in eyes with silicone oil tamponade for rhegmatogenous retinal detachment: a swept-source optical coherence tomography angiographystudy[J]. Sci Rep, 2020, 10(1): 2555. doi:10.1038/s41598-020-59504-3.
[18] Gaucher D, Chiappore JA, Paques M, et al. Microglial changes occur without neural cell death in diabetic retinopathy[J]. Vision Res, 2007, 47(5): 612-623. doi:10.1016/j.visres.2006.11.017.
[19] Quintyn JC, Brasseur G. Subretinal fluid in primary rhegmatogenous retinal detachment: physiopathology and composition[J]. Surv Ophthalmol, 2004, 49(1): 96-108. doi:10.1016/j.survophthal.2003.10.003.
[20] Snodderly DM, Weinhaus RS, Choi JC. Neural-vascular relationships in central Retina of macaque monkeys(Macaca fascicularis)[J]. J Neurosci, 1992, 12(4): 1169-1193.
[21] Scarinci F, Varano M, Parravano M. Retinal sensitivity loss correlates with deep capillary plexus impairment in diabetic macular ischemia[J]. J Ophthalmol, 2019, 2019: 7589841. doi:10.1155/2019/7589841.
[22] Lou B, Yuan Z, He L, et al. The changes of retinal saturation after long-term tamponade with silicone oil[J]. Biomed Res Int, 2015, 2015: 713828. doi:10.1155/2015/713828.
[23] Corvi F, Su L, Sadda SR. Evaluation of the inner choroid using OCT angiography[J]. Eye(Lond), 2021, 35(1): 110-120. doi:10.1038/s41433-020-01217-y.
[24] Mervin K, Valter K, Maslim J, et al. Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation[J]. Am J Ophthalmol, 1999,128(2): 155-164. doi:10.1016/s0002-9394(99)00104-x.
[25] Bae SH, Hwang JS, Yu HG. Comparative analysis of macular microstructure by spectral-domain optical coherence tomography before and after silicone oil removal[J]. Retina, 2012, 32(9): 1874-1883. doi:10.1097/IAE.0b013e318246907c.
[26] Dormegny L, Jeanjean LC, Liu XL, et al. Visual impairment and macular vascular remodeling secondary to retrograde maculopathy in retinal detachment treated with silicon oil tamponade[J]. Retina,2021, 41(2): 309-316. doi:10.1097/IAE.0000000000002812.
[27] Tanaka Y, Toyoda F, Shimmura-Tomita M, et al. Clinicopathological features of epiretinal membranes in eyes filled with silicone oil[J]. Clin Ophthalmol, 2018, 12: 1949-1957. doi:10.2147/OPTH.S180381.
[28] Wickham LJ, Asaria RH, Alexander R, et al. Immunopathology of intraocular silicone oil: Retina and epiretinal membranes[J]. Br J Ophthalmol, 2007, 91(2): 258-262. doi:10.1136/bjo.2006.103549.
[29] Nagpal M, Bhatt KJ, Jain P, et al. Correlation of spectral domain optical coherence tomography findings in sub-silicone oil foveal depression space and visual outcome in eyes undergoing silicone oil removal[J]. Taiwan J Ophthalmol, 2016, 6(1): 21-25. doi:10.1016/j.tjo.2015.11.001.
[30] Trivizki O, Zur D, Goldenberg D, et al. A novel finding of hyperreflective ma terial in the silicone-retina interfce: an optical coherence tomographic and histopathological study[J].Retin Phila Pa, 2020, 40(10): 2055-2060. doi:10.1097/IAE.0000000000002691.
[31] Saber EE, Bayoumy ASM, Elmohamady MN, et al. Macular microstructure and visual acuity after macula-off retinal detachment repair by 23-gauge vitrectomy plus silicone endotamponade[J]. Clin Ophthalmol Auckl N Z, 2018, 12: 2005-2013. doi:10.2147/OPTH.S181595.
[32] Lee SH, Han JW, Byeon SH, et al. Retinal layer segmentation after silicone oil or gas tamponade for macula-on retinal detachment using optical coherence tomography[J]. Retina, 2018, 38(2): 310-319. doi:10.1097/IAE.0000000000001533.
[33] Purtskhvanidze K, Hillenkamp J, Tode J, et al. Thinning of inner retinal layers after vitrectomy with silicone oil versus gas endotamponade in eyes with macula-off retinal detachment[J]. Ophthalmologica, 2017, 238(3): 124-132. doi:10.1159/000477743.
[34] Rabina G, Azem N, Barequet D, et al. Silicone oil tamponade effect on macular layer thickness and visual acuity[J]. Retina, 2020, 40(5): 998-1004. doi:10.1097/IAE.0000000000002464.
[35] Lo DM, Flaxel CJ, Fawzi AA. Macular effects of silicone oil tamponade: optical coherence tomography findings during and after silicone oil removal[J]. Curr Eye Res, 2017, 42(1): 98-103. doi:10.3109/02713683.2016.1146776.
[36] Zoric Geber M, Bencic G, Vatavuk Z, et al. Retinal nerve fibre layer thickness measurements after successful retinal detachment repair with silicone oil endotamponade[J]. Br J Ophthalmol, 2015,99(6): 853-858. doi:10.1136/bjophthalmol-2014-305839.
[37] Odrobina D, Go biewska J, Maroszyńska I. Choroidal thickness changes after vitrectomy with silicone oil tamponade for proliferative vitreoretinopathy retinal detachment[J]. Retina, 2017, 37(11): 2124-2129. doi:10.1097/IAE.0000000000001437.
[38] Karimi S, Entezari M, Nikkhah H, et al. Effects of intravitreal silicone oil on subfoveal choroidal thickness[J]. Ophthalmologica, 2018, 239(2/3): 159-166. doi:10.1159/000485851.
[39] Karasu B, Erıs E, Sonmez O, et al. The effect of silicone oil presence time on macular and choroidal thickness with macula-off rhegmatogenous retinal detachment[J]. J Fr Ophtalmol, 2020, 43(7): 626-634. doi:10.1016/j.jfo.2019.10.017.
[40] Yamada K, Kaneko H, Tsunekawa T, et al. Silicone oil-associated retinal light exposure under a surgical microscope[J]. Acta Ophthalmol, 2019, 97(5): e742-e746. doi:10.1111/aos.14038.
[41] Winter M, Eberhardt W, Scholz C, et al. Failure of potassium siphoning by Müller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy[J]. Invest Ophthalmol Vis Sci, 2000, 41(1): 256-261.
[42] Kaneko H, Takayama K, Asami T, et al. Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases[J]. Sci Rep, 2017, 7(1): 2640. doi:10.1038/s41598-017-03124-x.
[1] 赵娟,焦万珍,赵博军. UWFSS-OCTA检测糖尿病视网膜病变微循环的变化[J]. 山东大学耳鼻喉眼学报, 2026, 40(2): 80-86.
[2] 张欣,刘雅洁,李飞,黄春梅,张卉新,朱家斌. 重度OSA患者眼动脉及视网膜中央动脉血流动力学参数与AHI、LSaQ2的关联性[J]. 山东大学耳鼻喉眼学报, 2026, 40(2): 87-94.
[3] 朱明琼,李征,刘茹,田涛,彭婧利,吕倩怡,谭华霞. 基于OCT/OCTA的AI筛查系统在抗VEGF治疗糖尿病性黄斑水肿患者效果评价中的应用[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 68-73.
[4] 孙庆祝,沈健,陈星,吴雁冰,曾论. 代谢指标在预测糖尿病性黄斑水肿患者雷珠单抗疗效中的作用[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 74-81.
[5] 朱云龙,王平,高萌. 误诊为中浆及视网膜炎的后巩膜炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 99-105.
[6] 李世强,马燕,王家伟. 光学相干断层扫描血管成像在全身疾病中的临床应用研究进展[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 127-134.
[7] 高琳,何金梅,杨明祎. 糖尿病视网膜病变患者血清Sestrin2和NADPH氧化酶2水平与眼底病变的相关性[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 113-117.
[8] 丁术梁,王超凡,刘建亮. 眼内液检测指导精准治疗急性视网膜坏死1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 114-117.
[9] 王焕霞,王淑雅,王影,孙璇,黄杰,王兴荣. 孔源性视网膜脱离玻璃体切除术后继发黄斑前膜的危险因素分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 181-185.
[10] 毛一恒,冯洁,何润田. 高血脂对视网膜损害与脉络膜厚度关系研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 162-167.
[11] 张国明,魏文斌,林浩添,迟玮,张少冲,赵培泉,雷柏英,陈有信,王雨生,何明光,梁建宏,卢海,陆方,黄欣,梁小玲,赵欣予,吴桢泉,余震,崔凯璇,刘亚玲,项道满,陈长征,张自峰,林铎儒,于珊珊,孙悦,檀韬,陈燕先,彭婕,董力,程湧,朱雪梅,杨鹏,陈少滨. 人工智能技术辅助早产儿视网膜病变诊疗专家共识(2025)[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 1-5.
[12] 张露,王永晶,贾君,赵健楠,赵芳. 初发单眼眼前黑影飘动患者的光相干断层扫描特征[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 85-88.
[13] 肖哲,张胜娟,赵子琦,兴辰,李成泉,刘志强. Ultra Q:YAG激光治疗黄斑部视网膜前出血17例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 130-135.
[14] 许莞菁,孙雨浩,赵军. 姜黄素的抗氧化性对视网膜退行性疾病的影响[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 146-151.
[15] 杨淞月,张美霞. 单细胞RNA测序技术在视网膜中的研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 162-170.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!