M受体信号通路在近视发生发展中作用的研究进展

doi:10.6040/j.issn.1673-3770.0.2023.153

摘要/Abstract

摘要： M受体参与调节众多眼组织生理活动。研究表明,M受体可通过调节睫状肌收缩、调控视网膜和脉络膜中近视相关神经递质(如多巴胺)和生长因子(如转化生长因子β2)的表达来影响巩膜成纤维细胞增殖和基质金属蛋白酶2水平,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展。近年来,大量动物实验及临床研究均证实M受体拮抗剂可有效延缓近视进展。论文就不同眼组织(睫状肌、视网膜、脉络膜和巩膜)中M受体信号通路在近视发生发展中的作用进行简要综述,以期为近视相关机制研究及临床治疗提供思路。

关键词: 近视, M受体, 睫状肌, 视网膜, 脉络膜, 巩膜

Abstract: M receptors participate in regulating numerous physiological activities in eye tissues. Studies have shown that M receptors can regulate ciliary muscle contraction, regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid, and affect scleral fibroblast proliferation and matrix metalloproteinase-2 expression, which in turn affects scleral remodeling and axial growth, ultimately affecting the occurrence and development of myopia. In recent years, a large number of animal experiments and clinical studies have confirmed that M receptor antagonists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle, retina, choroid, and sclera), to provide ideas for the studing of myopia-related mechanisms and clinical treatment.

Key words: Myopia, M receptor, Ciliary muscle, Retina, Choroid, Sclera

中图分类号:

R778.1+1

张金木,郭滨,蒋文君,刘冬梅. M受体信号通路在近视发生发展中作用的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 160-164.

ZHANG Jinmu, GUO Bin, JIANG Wenjun, LIU Dongmei. Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 160-164.

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