关键词: 准分子激光原位角膜磨镶术, 机械板层刀, 飞秒激光, 角膜瓣厚度, 光学相干断层扫描

Abstract:

Objective    To compare the features of corneal flaps created using the FS200 and Moria M2 microkeratome 110μm-knife. Methods    A pilot and prospective study was designed. Ninety eyes of forty five patients were enrolled in this clinical trial. The patients were divided into the FS200 group (50 eyes) and the M2 microkeratome 110μm-knife group (40 eyes) with matching demography. Fourier-domain optical coherence tomography (RTVue OCT) was used to measure flap thickness by 10 settings on 90 corneas at one month post-operatively. The features of the laser in situ keratomileusis (LASIK) flaps were analyzed on the basis of the outcomes. Written informed consent was obtained from each patient prior to LASIK. Results    The mean flap thickness of the FS200 group was considerably thinner than that of the Moria 110 group (112.2±3.2μm versus 151.1±14.9μm), and the same result could be found in the variable range of the two groups (18.3±4.1 of the FS200 versus 42.6±14.5 of the M110) simultaneously.  The corneal flaps in the FS200 groups showed a flat shape and in the Moria 110 group showed a meniscus shape. The central flap thickness of the FS200 group was not evidently different from that of peripheral(P>0.05), but in the Moria 110 group, the central flap thickness was obviously thinner than the peripheral thickness (P<0.05).  Conclusion    The shape of flaps created using the FS200 is more uniform and closer to the expected thickness of 110μm than the ones created using the Moria M2 110 microkeratome.