尘螨变应性鼻炎皮下免疫治疗与舌下免疫治疗的荟萃分析

doi:10.6040/j.issn.1673-3770.0.2016.475

摘要/Abstract

Abstract: Objective To evaluate the effectiveness, compliance and safety of subcutaneous immunotherapy(SCIT)and sublingual immunotherapy(SLIT)in the treatment of dust mite-allergic rhinitis. Methods Randomized controlled trials or case-control studies of SCIT and SLIT in treatment of dust mite induced allergic rhinitis were searched in PubMed, EMBASE, Web of Science, the Cochrane Library, WANFANG, VIP, CNKI and CBMdisc databases. The literatures were quality evaluated, filtered and data extracted according to the standard of Oxford CASP, 2004, and the Review Manager 5.2 software was used for meta-analysis. Results 11 literatures including 712 patients were finally selected for analysis, 6 in Chinese and 5 in English. The results showed that there was no significant difference both in the improving nasal symptom scores(SMD=0.05; 95%CI: -0.27-0.38)and in the treatment compliance(RR=1.11, 95%CI: 0.98-1.26)between the SCIT and the SLIT groups. Each was safe and effective treatment although more adverse reactions were observed in SCIT than in SLIT(RR=1.89, 95% CI: 1.00-3.60). Conclusion Both SCIT and SLIT are safe and effective in the treatment of dust mite-allergic rhinitis, while adverse reactions were more frequently observed in SCIT.

Key words: Sublingual immunotherapy, Meta-analysis, Allergic rhinitis, Mites subcutaneous immunotherapy

中图分类号:

R765.21

万文锦,王文,程雷. 尘螨变应性鼻炎皮下免疫治疗与舌下免疫治疗的荟萃分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 103-108.

WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.

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