鼻腔冲洗联合鼻用糖皮质激素对AR患者FeNO、肺功能及生活质量的影响

doi:10.6040/j.issn.1673-3770.0.2018.236

摘要/Abstract

摘要： 目的探讨变应性鼻炎(AR)患者采用鼻腔冲洗联合鼻用糖皮质激素治疗对呼出气一氧化氮(FeNO)、肺功能及生活质量的影响。方法选取我院2016年3月至2017年3月收治的AR患者120例,采用随机数字表法分为观察组和对照组各60例,对照组采用布地奈德喷雾剂治疗,60 μg,每侧1次,每日早晚1次,连续治疗3个月;观察组早晚各采用100 mL生理盐水冲洗治疗,每侧早晚各冲洗1次,冲洗后采用布地奈德鼻喷雾剂治疗,连续治疗3个月。对比两组的FeNO、用力肺活量占预计值的百分比(FVC%)、第1秒用力肺活量占预计值的百分比(FEV₁%)、最高呼气流速(PEF)、平静呼气肺活量(VC%)占预计值的百分比及鼻-结膜炎相关生活质量问卷(RQLQ)评分。结果治疗后观察组与对照组FeNO水平分别为(750.2±89.4)×10^-10mol/L、(816.3±92.7)×10^-10mol/L,两组FeNO水平比较差异有统计学意义(t=-3.976, P<0.001)。治疗后,观察组FVC%、FEV₁%、PEF%、VC%水平高于对照组(t分别为3.207、4.211、2.780、3.272, P分别为0.002、<0.001、0.006、0.001)。治疗后观察组与对照组RQLQ评分分别为(29.0±6.4)、(34.4±7.0)分,两组比较差异有统计学意义(t=-4.410, P<0.001)。结论采用鼻腔冲洗联合鼻用糖皮质激素治疗AR能降低患者FeNO,在一定程度上改善患者肺功能,提高患者的生活质量。

关键词: 变应性鼻炎, 鼻腔冲洗, 鼻用糖皮质激素, 呼出气一氧化氮, 肺功能

Abstract: Objective To investigate the effects of nasal irrigation combined with glucocorticoid on exhaled nitric oxide(FeNO), pulmonary function, and quality of life in patients with allergic rhinitis(AR). Methods A total of 120 AR patients, admitted to our hospital from March 2016 to March 2017, were selected and randomly divided into the observation group and control group(n=60 cases, each). The control group was treated with budesonide spray(60 μg, once on each side)once every morning and evening for 3 months. The observation group was treated with saline irrigation(100 mL, once on each side)once every morning and evening, and then with budesonide nasal spray for 3 months. The FeNO, FVC%, FEV₁%, PEF, VC%, and RQLQ scores were compared between the two groups. Results The levels of FeNO in the observation group and the control group were(750.2±89.4)×10^-10mol/L and(816.3±92.7)×10^-10mol/L, respectively, following treatment. There was a significant difference in the levels of FeNO between the two groups(t=-3.976, P<0.001). After treatment, the levels of FVC, FEV₁%, PEF, and VC% in the observation group were higher than those in the control group(t=3.207, 4.211, 2.780, 3.272 and P=0.002, <0.001, 0.006, 0.001, respectively). The RQLQ scores of the observation group and the control group were(29.0±6.4)and(34.4±7.0), respectively, with a statistically significant difference(t=-4.410, P<0.001). Conclusion Nasal irrigation combined with nasal glucocorticoid therapy can reduce FeNO, and improve the pulmonary function and quality of life of AR patients to a certain extent.

Key words: Allergic rhinitis, Nasal irrigation, Nasal glucocorticoid, Exhaled nitric oxide, Pulmonary function

中图分类号:

R765.21

杜经纬,冯俊,马鹏,李志勇,李红光. 鼻腔冲洗联合鼻用糖皮质激素对AR患者FeNO、肺功能及生活质量的影响[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 124-127.

DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang. Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 124-127.

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