山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (3): 36-41.doi: 10.6040/j.issn.1673-3770.1.2019.021

• 研究进展 • 上一篇    下一篇

变应性鼻炎的遗传学研究现状

陆美萍1(),程雷1,2   

  1. 1. 南京医科大学第一附属医院 江苏省人民医院耳鼻咽喉科
    2. 南京医科大学国际变态反应研究中心，江苏 南京 210029
  • 收稿日期:2019-04-15 修回日期:2019-05-01 出版日期:2019-05-20 发布日期:2019-08-08
  • 通讯作者: 陆美萍 E-mail:lmp@njmu.edu.cn
  • 作者简介:陆美萍，医学博士，主任医师，副教授，硕士研究生导师。主要学术任职：中华医学会变态反应学分会青年委员，江苏省医学会变态反应学分会委员，江苏省医师协会变态反应医师分会委员，中国中西医结合学会耳鼻咽喉科专业委员会变态反应专家委员会常委，中国医师协会耳鼻咽喉科医师分会变态反应学组委员，江苏省医学会耳鼻咽喉头颈外科学分会鼻科学组副组长。曾荣获第三届全国耳鼻咽喉科医师大会“优秀青年医师奖”。主要研究领域为鼻部炎症与变态反应的遗传及分子机制，主持国家自然科学基金项目2项，发表学术论文20余篇
  • 基金资助:
    国家自然科学基金(81200747)

Current status of genetic research on allergic rhinitis

Meiping LU1(),Lei CHENG1,2   

  1. 1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University
    2. International Centre for Allergy Research, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-04-15 Revised:2019-05-01 Online:2019-05-20 Published:2019-08-08
  • Contact: Meiping LU E-mail:lmp@njmu.edu.cn

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摘要：

变应性鼻炎是基因和环境因素共同作用导致的鼻黏膜非感染性炎症性疾病，虽然目前对其发病机制已经有了较深入的了解，对遗传因素的研究也取得了较大进展，但这些遗传相关研究结果仅限于统计学层面，与临床应用还有很大距离。对变应性鼻炎相关基因的研究策略、基因与环境的交互作用、变应性疾病基因的重叠、表观遗传修饰及基因的转化研究方向做一综述。

关键词: 变应性鼻炎, 基因, 环境, 基因-环境交互作用, 表观遗传学, 精准医学

Abstract:

Allergic rhinitis is a non-infectious inflammatory disease of the nasal mucosa caused by a combination of genetic and environmental factors. Although a fair understanding of its pathogenesis already exits and research on genetic factors associated with this condition has made significant progress, these studies are still limited to achieving statistically significant results; however, their clinical applications have a long way to go. This article mainly introduces the research strategy on genes related to allergic rhinitis, their interaction with the environment, the sharing overlap of allergic disease genes, epigenetic modifications, and the direction of gene research transformation.

Key words: Allergic rhinitis, Genes, Environment, Gene-environment interaction, Epigenetics, Precision medicine

中图分类号: 

  • R765.4
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