自噬及其在青光眼中的研究进展

doi:10.6040/j.issn.1673-3770.0.2018.606

摘要/Abstract

摘要：

自噬是细胞通过降解更新细胞内异常的蛋白质、糖原、受损细胞器等累积物，并释放出对细胞有利的小分子物质进行二次利用，以维持细胞内稳态的一种细胞代谢过程。自噬调控异常与人体多种疾病相关，包括肿瘤、免疫性疾病、神经退行性疾病等。近年来发现，自噬参与青光眼疾病的生理病理过程，在其促进神经节细胞的生存和死亡方面仍存在一定的争议。故深入研究自噬的发生及机制，对全面了解自噬对青光眼疾病发生发展有着重要意义。

关键词: 自噬, 神经退行性疾病, 青光眼

Abstract:

Autophagy is a cellular metabolic process in which cells degrade and renew abnormal proteins, glycogen, damaged organelles, and other accumulations and release small molecules favorable for secondary utilization by cells to maintain intracellular homeostasis. It is a unique life phenomenon in eukaryotic cells and plays an important role in cell growth, development, and aging. Activation of abnormal autophagy is associated with various diseases, including tumor, immune disorders, and neurodegenerative diseases, in the human body. In recent years, it has been found that autophagy is involved in the physiological and pathological process of glaucoma; however, whether autophagy promotes the survival or death of retinal ganglion cells remains controversial. Therefore, an in-depth study on the occurrence and mechanism of autophagy is of great significance for a comprehensive understanding of the role of autophagy in the pathogenesis of glaucoma.

Key words: Autophagy, Neurodegenerative diseases, Glaucoma

中图分类号:

R774

刘瑞宝,赵颖,郭明璐,段钰,吴艳霞,路雪婧. 自噬及其在青光眼中的研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 158-161.

Ruibao LIU,Ying ZHAO,Minglu GUO,Yu DUAN,Yanxia WU,Xuejing LU. Autophagy and its research progress in glaucoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 158-161.

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