外泌体在甲状腺癌的研究进展

doi:10.6040/j.issn.1673-3770.0.2020.206

摘要/Abstract

摘要： 外泌体是一种直径50~140 nm的细胞外囊泡,包含DNA、RNA、蛋白质等多种内容物,几乎来源于所有类型的细胞。外泌体存在于血液、乳汁、尿液,通过传递生物活性分子在细胞间通讯中起着关键作用。论文综述外泌体的概况、功能及应用,总结外泌体miRNAs和circRNAs对甲状腺癌的影响及作为一种新型生物标志物的潜能。

关键词: 甲状腺癌, 外泌体, 细胞外囊泡, 微小RNA, 生物标志物

Abstract: The exosome are extracellular vesicle with a diameter of 50-140 nm, generated by almost all types of cell and carrying nucleic acids, proteins, lipids, and metabolites. They are found in all biological fluids such as blood,milk,urine etc.and play a key role in intercellular communication by delivering active biomolecules. This paper rviews the general situation, functions and applications of exosomes, summarize the effects of exosomal miRNAs and circRNAs in thyroid carcinoma and the potential as a new type of biomarkers.

Key words: Thyroid cancers, Exosome, Extracellular vesicles, MicroRNAs(miRNA), Biomarkers

中图分类号:

R736.1

张轶轶,薛刚,金春亭. 外泌体在甲状腺癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 131-135.

ZHANG Yiyi,XUE Gang, JIN Chunting. Research progress of exosomes in thyroid cancers[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 131-135.

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