SIRT1激动剂白藜芦醇在眼部疾病中的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.070

摘要/Abstract

摘要： Sirtuins是一类组蛋白去乙酰化酶,它通过控制基因表达、DNA修复、代谢、氧化应激反应、线粒体功能等生物学进程来调节多种活动,而这类酶中,被研究最多的是沉默信息调节因子-1(sirtuin 1, SIRT1)。白藜芦醇作为上调SIRT1活性的天然多酚类化合物,具有很强的抗氧化和抗炎作用,在心脏保护、神经保护、化疗和延缓衰老等方面被广泛研究。而氧化应激和炎症在眼部疾病的发生和发展中起着关键的作用,这些疾病会导致视力渐进性丧失和(或)致盲。综述白藜芦醇在眼部疾病中的潜在用途及其应用的限制性。

关键词: 白藜芦醇, 沉默信息调节因子-1, 氧化应激, 组蛋白去乙酰化酶

Abstract: Sirtuins are a class of histone deacetylases that regulate a variety of activities through the control of gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and other biological processes. Sirtuin 1(SIRT1)has been most widely studied. Resveratrol is a natural polyphenolic compound that upregulates SIRT1 activity. Resveratrol has strong antioxidant and anti-inflammatory activities, and has been widely studied in cardiac protection, neuroprotection, chemotherapy, and anti-aging. Oxidative stress and inflammation play key roles in the development and progression of eye diseases, which can lead to progressive vision loss and even blindness. This article briefly reviews the potential use of resveratrol in ocular diseases and the limitations of its applications.

Key words: Resveratrol, SIRT1, Oxidative stress, Inflammation, Histone deacetylase

中图分类号:

R771

张依,王文俊，杨安怀. SIRT1激动剂白藜芦醇在眼部疾病中的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 151-156.

ZHANG Yi, WANG Wenjun,YANG Anhuai. Research progress of SIRT1 activation by resveratrol in ocular diseases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 151-156.

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