山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (4): 75-85.doi: 10.6040/j.issn.1673-3770.0.2022.189

• • 上一篇    下一篇

穴位贴敷治疗小儿过敏性鼻炎随机对照试验的Meta分析

毕晓云1,马本绪2,王心茹1,李旭豪1,杨继国1   

  1. 1.山东中医药大学 针灸推拿学院, 山东 济南 250355;
    2.青岛市中心医院 针灸科, 山东 青岛 266000
  • 发布日期:2023-07-27
  • 通讯作者: 杨继国. E-mail:jiguoyang@126.com
  • 基金资助:
    齐鲁医派中医学术流派传承项目(鲁卫函［2020］132号)

Meta-analysis of randomized controlled trials of acupoint application in treatment of children with allergic rhinitis

BI Xiaoyun1, MA Benxu2, WANG Xinru1, LI Xuhao1, YANG Jiguo1   

  1. 1. School of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China2. Department of Acupuncture and Moxibustion, Qingdao Central Hospital, Qingdao 266000, Shandong, China
  • Published:2023-07-27

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摘要： 目的 采用Meta分析方法评估穴位贴敷治疗小儿过敏性鼻炎的疗效。 方法 全面检索PubMed、The Cochrane Library、中国知网、维普数据库、万方数据资源系统、中国生物医学文献数据库。检索时间从各数据库建立时间至2022年4月17日发表的关于穴位贴敷治疗小儿过敏性鼻炎的随机对照试验,将相关结局指标采用RevMan 5.3及Stata 14.0软件进行分析。 结果 纳入19项随机对照试验,总样本量1669例。Meta分析结果显示,穴位贴敷联合中药治疗小儿过敏性鼻炎有效率优于单纯中药对照组(RR=1.12, 95%CI［1.03,1.21］, P=0.006);穴位贴敷联合西药治疗小儿过敏性鼻炎有效率优于单纯西药(RR=1.28, 95%CI［1.14,1.44］, P<0.001);单纯穴位贴敷临床效果优于单纯应用西药治疗(RR=1.23, 95%CI［1.15,1.31］, P<0.001);单纯穴位贴敷与单纯应用中药治疗临床效果相当(RR=1.45, 95%CI［0.84,2.49］, P=0.18)。穴位贴敷与西药均可降低嗜酸性粒细胞、免疫球蛋白E水平,但两者效果相当;穴位贴敷可降低白细胞介素-4水平,提升干扰素-γ水平,改善过敏性鼻炎患儿临床症状 。 结论 穴位贴敷疗法对小儿过敏性鼻炎的临床治疗效果显著,安全可靠,适宜广泛推广应用。

关键词: 穴位贴敷, 小儿过敏性鼻炎, Meta分析

Abstract: Objective To evaluate the efficacy of acupoint application in the treatment of children with allergic rhinitis(AR)by meta-analysis. Methods PubMed, the Cochrane Library, CNKI, VIP, WanFang, and CBM, were searched comprehensively for randomized controlled trials(RCT)of acupoint application used in treatment of children with allergic rhinitis, with retrieval time set from establishment of each database to April 17, 2022. RevMan 5.3 and Stata 14.0 were used to analyze relevant outcome indicators. Results A total of 19 RCTs were included, with a total sample size of 1669 cases. Meta-analysis results showed that the effective rate of acupoint application combined with traditional Chinese medicine in the treatment of children with allergic rhinitis was significantly better than the control group of traditional Chinese medicine alone(RR=1.12, 95%CI ［1.03,1.21］, P=0.006). The effective rate of acupoint application combined with Western medicine in the treatment of children with allergic rhinitis was significantly better than Western medicine alone(RR=1.28, 95%CI ［1.14,1.44］, P<0.001). The clinical effect of acupoint application alone was significantly better than Western medicine alone(RR=1.23, 95%CI ［1.15,1.31］, P<0.001). The clinical effect of simple acupoint application is equivalent to that of simple application of traditional Chinese medicine(RR=1.45, 95%CI ［0.84,2.49］, P=0.18). Acupoint application and Western medicine can both reduce Eosinophil and Immunoglobulin E levels, but there were no differences in reduction effects. Acupoint application can significantly reduce Interleukin-4 levels, enhance Interferon-γ levels, and improve clinical symptoms. Conclusion Acupoint application therapy is effective, safe, and reliable for clinical treatment of children with allergic rhinitis, and can be widely used.

Key words: Acupoint application, Children with allergic rhinitis, Meta-analysis

中图分类号: 

  • R765
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