喉癌中PTTG的表达及其与bFGF和微血管密度的关系

山东大学耳鼻喉眼学报

喉癌中PTTG的表达及其与bFGF和
微血管密度的关系

梁昆¹，姚磊¹，马超²，孙睿杰¹，陆忠华¹，雷大鹏¹，潘新良¹

（1. 山东大学齐鲁医院耳鼻咽喉头颈外科； 2. 山东大学卫生部耳鼻喉科学重点实验室，济南 250012）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-04-16 发布日期:2009-04-16

Expressions of PTTG and bFGF proteins and their relationship to MVD in laryngeal carcinoma

LIANG Kun¹, YAO Lei¹, MA Chao²,　SUN Ruijie¹,　LU Zhonghua¹,　LEI Dapeng¹,　PAN Xinliang¹

(1. Department of Otorhinolaryngology & Head and Neck Surgery， Qilu Hospital of Shandong University， Jinan 250012， China；
2. Key Laboratory of Otorhinolaryngology, Ministry of Health, Shandong University, Shandong University, Jinan 250012, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-04-16 Published:2009-04-16

摘要/Abstract

摘要： 目的探讨喉癌中PTTG、bFGF的表达以及在新生血管生成过程中的作用。方法应用免疫组化SP法分别检测57例喉癌、26例癌旁和9例正常喉黏膜中PTTG、bFGF蛋白的表达，用CD34标记并计数肿瘤内微血管密度。结果喉癌中PTTG蛋白和bFGF蛋白表达率分别为84.2%和78.9%，明显高于癌旁及正常喉黏膜的表达率（P＜0.05）。PTTG的表达与肿瘤分化程度、临床分期相关和淋巴结转移差异有统计学意义（P＜0.05），bFGF的表达与肿瘤分化程度和淋巴结转移差异有统计学意义（P＜0.05），与临床分期差异无统计学意义(P＞0.05)。两者的表达均与患者年龄、性别和肿瘤原发部位差异无统计学意义(P＞0.05)，且两者之间呈显著正相关（P＜0.05）。喉癌中MVD值明显大于癌旁和正常喉黏膜（P＜0.05）,并与淋巴结转移显著相关（P＜0.05），MVD分别与PTTG和bFGF的表达相关（P＜0.05）。结论PTTG和bFGF的表达与喉癌的临床病理学特征密切相关，二者的检测将有助于喉癌的诊断、评估喉癌患者的恶性程度。

关键词: 喉肿瘤, 垂体肿瘤转化基因, 碱性成纤维细胞生长因子, 微血管密度, 免疫组织化学

Abstract:

To explore expressions of the pituitary tumortransforming gene(PTTG) and basic fibroblast growth factor(bFGF) proteins and their relationship to MVD in laryngeal carcinoma. MethodsExpressions of PTTG and bFGF were determined by the immunohistochemical SP method in 57 cases of laryngeal carcinoma, and compared with those in 26 cases of paracarcinoma tissues and 9 cases of normal tissues. MVD in laryngeal carcinoma was evaluated by immunohistochemical staining with antibody CD34. ResultsThe positive rate of PTTG and bFGF was 84.2% and 78.9% in laryngeal carcinoma, which was significant higher than those in paracarcinoma tissues and normal tissues(P＜0.05). Expression of PTTG was associated with histological differentiation and clinical stages(P＜0.05) and was significantly associated with lymph node metastases(P＜0.05), but was not associated with age, gender and primary lesions(P＞0.05). Expression of bFGF was significantly associated with histological differentiation and lymph node metastases(P＜0.05), but was not associated with age, gender, clinical stages and primary lesions(P＞0.05). There was a significant correlation between expression of PTTG and bFGF(P＜0.05). The value of MVD in laryngeal carcinoma was significantly higher than that in paracarcinoma tissues and normal tissues(P＜0.05), and was significantly associated with lymph node metastases(P＜0.05),　but not associated with age, gender, histological differentiation, clinical stages and primary lesions(P＞0.05). Expressions of PTTG and bFGF were correlated with MVD in laryngeal carcinoma(P＜0.05). ConclusionIncreased PTTG may play an

中图分类号:

R739.65

梁昆1 ，姚磊1 ，马超2 ，孙睿杰1 ，陆忠华1 ，雷大鹏1 ，潘新良1
. 喉癌中PTTG的表达及其与bFGF和
微血管密度的关系[J]. 山东大学耳鼻喉眼学报, 2009, 23(2): 15-19 .

LIANG Kun¹, YAO Lei¹, MA Chao²,　SUN Ruijie¹,　LU Zhonghua¹,　LEI Dapeng¹,　PAN Xinliang¹
.

Expressions of PTTG and bFGF proteins and their relationship to MVD in laryngeal carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(2): 15-19 .

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