JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of EGFR, cMet and HER2/neu in chordoma and other cancers

Paul Weinberger2,Clarence Sasaki2   

  1. 1. Department of Otolaryngology & Head and Neck Surgery， Shanghai First People′s Hospital,Shanghai 200080, China; 2. Department of Otolaryngology; 3. Department of Pathology;
  • Received:2005-10-29 Revised:2006-11-19 Online:2006-12-24 Published:2006-12-24
  • Contact: YU Zi-wei

Abstract: To investigate the expression of cMet, cErbb2 and EGFR in 12 chordomas, based on the current and future availability of targeted molecular inhibitors. Method: Protein expression levels were analyzed by immunohistochemical analysis from 12 chordomas and 51 other tumors from 17 assorted solid tissue tumor types using multitumored tissue microarray. Results: Most chordomas displayed strong expression of EGFR and cMet, while a variable level of expression of HER2/neu was observed. In addition, we noted a strong correlation between EGFR and cMet expression, especially for primary chordomas (P=0.006). Conclusions: Chordoma, like many other solidtissue tumors, expresses HER2/neu, EGFR and cMet. Most chordoma has strong expression of both cMet and EGFR. Inhibitors to EGFR are already in clinical use for other solid tissue tumors and represent a potentially viable experimental treatment option for refractory chordoma.

Key words: Receptor tyrosine kinase, Targeted therapy, Chordoma, Immunohistochemistry

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