JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of angiopoietin-2 and its clinical significance on Juvenile nasopharyngeal angiofibroma

WU Xian-min1，LI Zhi-chun1，ZHANG Sheng2，YI Zi-xiang1， LIN Gong-biao1   

  1. 1. Department of Otorhinolaryngology；2.Department of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, Fujian
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: WU Xian-min

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Abstract: Objective To investigate the expression of angiopoietin-2(Ang-2) in Juvenile nasopharyngeal angiofibroma(JNA) and its relationship with vascularization and dilatancy growth. Methods Expression of Ang-2 was determined in 30 cases of JNA and 20 cases of chronic inflammation tissues of the pharynx nasalis by immunohistochemistry. Vascular endothelial cells were marked by CD34 and the microvessel density (MVD) was also determined in the above tissue specimens. Results The positive rate of Ang-2 protein was 76.67% in JNA， which was higher than that in chronic inflammation tissues of the pharynx nasalis. The positive rate of Ang-2 proteins was 90％ in stages Ⅲ-Ⅳ， which was obviously higher than that in stagesⅠ-Ⅱ. The expression rate of CD34 in JNA was lower than that in chronic inflammation tissues of the pharynx nasalis（P<0.05）. Conclusions Ang-2 participates in the vascularization of JNA and has some relatioge and tumor′s dilatancy growth.

Key words: Juvenile nasopharyngeal angiofibroma, Angiopoietin-2, Immunohistochemistry

CLC Number: 

  • R739.65
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