JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

Previous Articles     Next Articles

The association between rs2910164 G>C polymorphism in pre-microRNA-146a and laryngeal cancer in Jiangsu Han population

LIN Dan, DONG Wei-da, LU Mei-ping, XING Guang-qian, DONG Jia-di, ZHANG Wei-qiang   

  1. Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2014-01-13 Online:2014-04-16 Published:2014-04-16

PDF (PC)

450

Abstract: Objective    To investigate the association between rs2910164 G>C polymorphism in pre-microRNA-146a (pre-miR-146a) and laryngeal cancer. Methods    We conducted a case-control study with 204 cases and 440 cancer-free controls by collecting general and clinical characteristics, and genotyped the rs2910164 polymorphism using the TaqMan method. Logistic regression model was used to evaluate genetic effects on the development of laryngeal cancer. Results    We found that rs2910164 was significantly associated with the increased laryngeal cancer risk (GC/CC vs. CC: OR adjusted=2.49, 95% CI=1.57-3.94). In the stratification analysis, pronounced among smokers, drinkers and no family history of cancer (P<0.05 for all) were increased risks, and rs2910164 in combination with smoking and drinking effected more deeply(OR=6.39, 95% CI=2.72-15.0 for smoking with rs2910164 GC/CC; OR=4.19, 95% CI=2.24-7.83 for drinking with rs2910164 GC/CC). Conclusion    The rs2910164 C allele in miR-146a was associated with increased laryngeal cancer risk, which may act as a potential biomarker for diagnosis of laryngeal cancer.

Key words: MicroRNA-146a, Genetic susceptibility, Laryngeal cancer, Single nucleotide polymorphism

CLC Number: 

  • R739.62
[1] XIAO Junhua, PAN Qingchun, JIN Shu. Trend and projection of larynx cancer mortality caused by occupational exposure to sulfuric acid [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 55-61.
[2] XIE Feng, XU Zhenju, WU Ce, LIU Jie, ZANG Chuanshan, ZHANG Longxiao, HAN Min. Clinicopathologic and survival analysis of laryngeal neuroendocrine neoplasm in 26 cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 79-86.
[3] QU Xiangyu, ZHU Han, LIU Zhonglu, MU Yakui, GUO Wentao, ZHANG Hua. Application of epiglottic tongue flap in supraglottic defect repair of laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 77-84.
[4] WANG Jingsong, YU Can, ZHANG Xi, DENG Qicheng, XIE Zhuoliang, ZHAO Rui, WEN Bei, LIU Hai. Expression and clinical significance of KRT4 in laryngeal carcinoma and adjacent normal mucosal tissues [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 12-17.
[5] ZHANG Zhuping, YE Qi, GUO Bei, LIN Ling. Diagnostic utility of folate receptor-positive circulating tumor cells in patients with laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 50-53.
[6] ZHANG Xi, DENG Qicheng, ZHANG Zhen, CHEN Yao, WANG Jingsong, ZHAO Rui, LIU Hai. Effect of nutritional support on postoperative pharyngeal fistula after laryngeal cancer surgery: a Meta-analysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 51-59.
[7] XU Chong, WANG Xiaoting, YI Hongliang. Single-cell sequencing analysis of laryngeal cancer and its microenvironmental metabolism-related target genes [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 33-38.
[8] LI Cong, LI Ling, LIU Tingyan, CHEN Liang. Research progress on influencing factors of aminoglycoside antibiotic ototoxicity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 128-134.
[9] HUANG Hengfeng, MA Kunpeng, YANG Di, ZHANG Lijun, ZHANG Shenglin. Expression and clinical significance of miR-181b-5P and EPB41L3 protein in laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 41-46.
[10] WANG MeiOverview,LI ZhihaiGuidance. Laryngeal cancer stem cells: potential therapeutic targets for overcoming multidrug resistance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 120-128.
[11] LIU Houjun, ZHANG Qian, CHENG You, XUE Fei, XU Li, WU Minghai. Relationships between RANTES gene polymorphisms and chronic sinusitis with bilateral nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 165-170.
[12] WANG Xiaoting, CHEN Zhengnong, YI Hongliang. Transcriptomic analysis of glutamine deprivation on laryngeal carcinoma cells [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 26-31.
[13] LI Yanjie, JIA Jian, YANG Ping, WAN Baoluo. Study on the value of tumor abnormal protein in clinical diagnosis of laryngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 70-74.
[14] LI Wenjing,LIU Ming. Research progress on the relationship between the C2H2 zinc finger protein family and laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 125-130.
[15] . The swallowing function recovery study on tongue flap after horizontal hemilaryngectomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 127-131.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd