JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 40-42.doi: 10.6040/j.issn.1673-3770.0.2015.310

Previous Articles     Next Articles

Expression and significance of ERK5 protein in nasal polyps cells.

GAO Zhenfeng1, TAO Qian2, CAI Xiaolan3   

  • Received:2015-07-28 Online:2016-02-16 Published:2016-02-16

PDF (PC)

734

Abstract: Objective To investigate the expression and significance of extracellular regulated protein kinases 5(ERK5)protein in nasal polyps cells. Methods The clinical data of patients with chronic rhinosinusitis in our hospital from January 2013 to December 2014 was analyzed, in which 37 patients with nasal polyps were treated as the observation group(CRSwNP group)and 35 patients without nasal polyps were treated as the control group(CRSsNP group). Results Serum TNF-α(t=16.7, P<16.7), IL-5 (t=13.81, P<0.001)and IL-8(t=8.642, P<0.001)levels of the patients in the CRSwNP group were significantly higher than those in the control group, the difference had statistical significance(P>0.05). The results of western boltting test found that ERK5 protein expression level in the CRSwNP group was significantly higher than in the control group(gamma ratio 1.21±0.16 vs 0.36±0.04, P<0.01, n=37). By using Pearson correlation test ERK5 protein expression of the CRSwNP group had significant positive correlation with TNF-α(r=0.521, P=0.001)and IL-8(r=0.479, P=0.479)level. Conclusion ERK5 protein in patients with nasal polyps show high expression level and positive correlation with TNF-α and IL-8 level.

Key words: Nasal polyp, Extracellular regulated protein kinases 5, ELISA

CLC Number: 

  • R765.2
[1] Miranda M, Rozali E, Khanna K K, et al. MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments[J]. Oncoscience, 2015, 2(2):99-101.
[2] Finegan K G, Perez-Madrigal D, Hitchin J R, et al. ERK5 is a critical mediator of inflammation-driven cancer[J]. Cancer Res, 2015, 75(4):742-753.
[3] 尹宏, 黄欣, 王海燕, 等. ERK5在胃腺癌组织中的表达及临床意义[J]. 中国现代医学杂志, 2014, 24(20):56-60. YIN Hong, HUANG Xin, WANG Haiyan, et al. Expression of ERK5 in gastric adenocarcinoma and its clinical significance[J]. Chin J Mod Med, 2014, 24(20):56-60.
[4] Yue B, Ren Q X, Su T, et al. ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway[J]. Eur Rev Med Pharmacol Sci, 2014, 18(18):2640-2647.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 慢性鼻-鼻窦炎诊断和治疗指南(2012, 昆明)[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(2):92-94.
[6] 王耀晟, 程晓曙, 洪葵, 等. 细胞外信号调节蛋白激酶5/凋亡调节蛋白信号途径在低温诱导心肌细胞损伤及凋亡中的调控作用[J]. 中国循环杂志, 2014(7):540-544. WANG Yaosheng, CHENG Xiaoshu, HONG Kui, et al. The regulative role of ERK5/Bim pathway in hypothermal stimulation induced neonatal rats cardiomyocytes injury and apoptosis[J]. Chin Circ J, 2014(7):540-544.
[7] Xiu Q, Meng C, Li L, et al. Allergic factors affect on severity of chronic rhinosinusitis and postoperative outcomes[J]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2015, 29(1):34-38, 44.
[8] Koseoglu S, Ozcan K M, Ikinciogullari A, et al. Evaluation of autoinflammatory disease genes in nasal polyposis[J]. Turk J Med Sci, 2015, 45(1):136-140.
[9] Wang C, Lou H, Wang X, et al. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps[J]. J Allergy Clin Immunol, 2015, 135(4):922-929.e6.
[10] Poposki J A, Peterson S, Welch K, et al. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis[J]. Clin Exp Allergy, 2015, 45(2):384-393.
[11] Heo K S, Cushman H J, Akaike M, et al. ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis[J]. Circulation, 2014, 130(2):180-191.
[1] FENG Sicong, YU Xiaolan, LOU Dan. Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 31-39.
[2] ZHANG Jiaqi, YUAN Ye, HONG Chen, GU Min, CHENG Lei, LU Meiping. Mendelian randomization study of gut microbiota, chronic sinusitis, and nasal polyps: Causal relationships and metabolite-mediated effects [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 49-60.
[3] ZHANG Guangling, CHEN Xingxue, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao,WANG Guangke. The expression and function of Tespa1 in chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 35-42.
[4] CAO Zhengyong, LI Xiaobo. Comparison of the safety and efficacy of short-course postoperative topical glucocorticoid adjuvant therapy for eCRSwNP combined with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 43-50.
[5] WANG Wenqing, ZHANG Dan, ZHU Mengdi, WANG Luyang, YANG Peipei, SUN Sisi, ZHANG Qiumin, ZHOU Hui. Changes of clinical and histopathological characteristics in recurrent chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 46-53.
[6] WANG Aowei, SHI Wenjie. Study on correlation between traditional Chinese medicine syndrome types and TFH cell related factors in CRSwNP [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 54-60.
[7] ZHANG Jie, NIMA Jizong, XU Xiaodong, ZHOU Jing, LIU Jianmin, LUO Yirui, DU Jintao, BA Luo. Effect of Crocin on Type 2 inflammation in eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 61-67.
[8] SHI Zhonggang, CAI Xiaolan, LI Xuezhong, ZHANG Liqiang, FENG Xin. Maxillary cyst with inverted papilloma: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 123-129.
[9] ZHANG Yunqiu, REN Xiumin, XU Ou, DONG Jinhui, WANG Jianxing. Research progress on omalizumab targeted therapy for chronic sinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 136-140.
[10] CHEN Xingxue, ZHANG Guangling, WU Tianyi, WANG Weiwei, SUN Zhanwei, LI Shichao, WANG Guangke. Analysis of anti-IL-4Rα monoclonal antibody and endoscopic sinus surgery in the treatment of eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 43-54.
[11] ZHANG Shihan, LIU Hongbing. Effect of matrix metalloproteinase on tissue remodeling in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 116-123.
[12] YAN Huijuan, XIAO Xuping, ZHONG Yu. Expression and clinical significance of IL-29 and TLR4 in eosinophil infiltrated nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 122-127.
[13] SUN Xiwen, LUO Chunyu, LI Zhipeng, ZHANG Weitian. Role of ferroptosis in inflammatory diseases of the respiratory tract: a review of recent advances [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 24-32.
[14] WANG Lixue, ZENG Yi, WANG Lixin, PENG Xianbing. Clinical observation of the effect of infiltrating Biprofen Gelatin Sponge after functional endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 16-25.
[15] ZHU Yu, ZHU Xinhua. Research progress on the role of TH2 cytokines in Type2 chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 156-161.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd