JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (2): 112-115.doi: 10.6040/j.issn.1673-3770.0.2017.042

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Progress of tight junctions and chronic rhinosinusitis.

  

  1. Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China
  • Received:2017-02-01 Online:2017-04-16 Published:2017-04-16

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Abstract: Chronic rhinosinusitis(CRS)is a common inflammatory disease. TJs are the most apically located of the intercellular junctional complexes, and may have critical role in barrier function of epithelium. Found in the recent years, the changes of tight junctions(TJs)may play important roles in the pathogenesis of chronic rhinosinusitis. The component of TJs are the spot-light in current area of research. This review article explores the pathogenesis of CRS, especially the tight junctions, for the sake of further understanding of CRS.

Key words: Tight junctions, Chronic rhinosinusitis

CLC Number: 

  • R765.4
[1] Azizzadeh DA, Jalali NM, Davati A, et al. Expression of vascular endothelial growth factor in nasal polyp and chronic rhinosinusitis[J]. Iran J Pathol, 2016, 11(3):231-237.
[2] London NR, Tharakan A, Ramanathan M. The role of innate immunity and aeroallergens in chronic rhinosinusitis[J]. Adv Otorhinolaryngol, 2016, 79:69-77.
[3] Hulse KE. Immune Mechanisms of Chronic Rhinosinusitis[J]. Curr Allergy Asth Rep, 2016, 16(1):1-8.
[4] Chang EH, Pezzulo AA, Zabner J. Do Cell Junction Protein Mutations Cause an Airway Phenotype in Mice or Humans?[J]. Am J Resp Cell Mol Biol, 2011, 45(2):202-220.
[5] Wei Y, Han M, Wen W, et al. Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment[J]. Curr Opin Allergy Clin Immunol, 2015, 16(1):31-38.
[6] Rogers GA, Den BK, Parkos CA, et al. Epithelial tight junction alterations in nasal polyposis[J]. Int Forum Allergy Rhinol, 2011, 1(1):50-54.
[7] Turner JR, Buschmann MM, Sailer A, et al. The role of molecular remodeling in differential regulation of tight junction permeability[J]. Semin Cell Develop Biol, 2014, 36(2):204-212.
[8] Itallie CMV, Anderson JM. Architecture of tight junctions and principles of molecular composition[J]. Semin Cell Develop Biol, 2014, 36(1):157-165.
[9] Soini Y. Tight junctions in lung cancer and lung metastasis: a review[J]. Int J Clin Exp Pathol, 2012, 5(2):126-136.
[10] Anderson JM, Van Itallie CM. Physiology and function of the tight junction[J]. Cold Spring Harbor Perspect Biol, 2009, 1(2):a002584.
[11] Dokladny K, Zuhl MN, Moseley PL. Intestinal epithelial barrier function and tight junction proteins with heat and exercise[J]. J App Physiol, 2015, 120(6):692-701.
[12] Kim HJ, Cronin M, Ahrens K, et al. A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis[J]. Veterin Dermatol, 2015, 27(1):40-e11.
[13] Park SW, Kim JH, Park SM, et al. RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium[J]. Oncotarget, 2015, 6(34):35263-35273.
[14] Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches[J]. J Allergy Clin Immunol, 2009, 124(1):35-36.
[15] Li Y, Wang X, Wang R, et al. The expression of epithelial intercellular junctional proteins in the sinonasal tissue of subjects with chronic rhinosinusitis: a histopathologic study[J]. ORL, 2014, 76(2):110-119.
[16] Kojima T, Go M, Takano K, et al. Regulation of tight junctions in upper airway epithelium[J]. Biomed Res Int, 2013, 2013(2):947072.
[17] Günzel D, Yu AS. Claudins and the modulation of tight junction permeability[J]. Physiol Rev, 2013, 93(2): 525-569.
[18] Steelant B, Seys SF, Boeckxstaens G, et al. Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease[J]. Rhinol, 2016, 54(3):195-205.
[19] Wise SK, Laury AM, Katz EH, et al. Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression[J]. Int Forum Allergy Rhinol, 2014, 4(5):361-370.
[20] Chen X, Luo X, Han M, et al. Corticosteroid regulates epithelial occludin expression in nasal polyps through a mkp-1-dependent pathway[J]. ORL, 2014, 76(5):248-256.
[21] Philip M. Occludin: one protein, many forms[J]. Cummins Mol Cell Biol, 2012, 32(2): 242-250.
[22] Phattarataratip E, Sappayatosok K. Expression of claudin-5, claudin-7 and occludin in oral squamous cell carcinoma and their clinico-pathological significance[J]. J Clin Exper Dent, 2016, 8(3):299-306.
[23] Chen Y, Zhang HS, Fong GH, et al. PHD3 stabilizes the tight junction protein occludin and protects intestinal epithelial barrier function[J]. J Biol Chem, 2015, 290(33):20580-20589.
[24] Zhao H, Zhao C, Dong Y, et al. Inhibition of miR122a by lactobacillus rhamnosus GG culture supernatant increases intestinal occludin expression and protects mice from alcoholic liver disease[J]. Toxicol Lett, 2015, 234(3):194-200.
[25] Xia YP, He QW, Li YN, et al. Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage[J]. Plos One, 2013, 8(7):e68891.
[26] Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4[J]. J Allergy Clin Immunol, 2012, 130(5):1087-1096.
[27] Meng J, Zhou P, Liu Y, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling[J]. Plos One, 2013, 8(12):e82373.
[28] Nomura K, Obata K, Keira T, et al. Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells[J]. Respirat Res, 2014, 15(1):21-33.
[29] Garridourbani S, Bradfield PF, Imhof BA. Tight junction dynamics: the role of junctional adhesion molecules(JAMs)[J]. Cell Tissue Res, 2014, 355(3):701-715.
[30] Arcangeli ML, Frontera V, Aurrandlions M. Function of junctional adhesion molecules(JAMs)in leukocyte migration and homeostasis[J]. Arch Immunol Et Ther Exper, 2012, 61(1):15-23.
[31] Monteiro AC, Parkos CA. Intracellular mediators of JAM-A-dependent epithelial barrier function[J]. Ann New York Acad Sci, 2012, 1257(1):115-124.
[32] Den Beste KA, Hoddeson EK, Parkos CA, et al. Epithelial permeability alterations in an in vitro air–liquid interface model of allergic fungal rhinosinusitis [J]. Int Forum Allergy Rhinol, 2013, 3(1):19-25.
[33] Mariano C, Sasaki H, Brites D, et al. A look at tricellulin and its role in tight junction formation and maintenance[J]. Eur J Cell Biol, 2011, 90(10):787-796.
[34] Takasawa A, Kojima T, Ninomiya T, et al. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions[J]. Cell Tissue Res, 2013, 351(1):73-84.
[35] Mandon M, Cyr DG. Tricellulin and its role in the epididymal epithelium of the rat[J]. Biol Reprod, 2015, 92(3):66.
[36] Ohkuni T, Kojima T, Ogasawara N, et al. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro[J]. Med Molec Morphol, 2009, 42(4):204-211.
[37] Suzuki H, Koizumi H, Ikezaki S, et al. Electrical Impedance and Expression of Tight Junction Components of the Nasal Turbinate and Polyp[J]. ORL, 2015, 78(1):16-25.
[38] Zimmerman SP, Hueschen CL, Malide D, et al. Sorting nexin 27(SNX27)associates with zonula occludens-2(ZO-2)and modulates the epithelial tight junction[J]. Biochem J, 2013, 455(1):95-106.
[39] 李颖, 范尔钟, 伯铭羽,等. 细胞连接在慢性鼻窦炎中的表达及意义[J]. 首都医科大学学报, 2013, 34(6):799-804. LI Ying, FAN Erzhong, BO Mingyu, et al. Expression of cell junctions in the tissue of chronic rhinosinusitis[J]. J Capital Med Univ, 2013, 34(6):799-804.
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