JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (6): 46-48.doi: 10.6040/j.issn.1673-3770.0.2017.290

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Expression of chemokine ligand 27 in secondary middle ear cholesteatoma.

ZHANG Menglu, LI Yongtuan.   

  1. Department of Otolaryngology &Head and Neck Surgery, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266000, Shandong, China
  • Received:2017-07-03 Online:2017-12-16 Published:2017-12-16

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Abstract: Objective To explore the pathological expression of chemokine ligand 27(CCL27)and discuss its possible clinical significance in secondary middle ear cholesteatoma. Methods The SP immunohistochemical staining technique was applied to detect the expression of CCL27 in 30 samples of secondary middle ear cholesteatoma tissue and 30 samples of normal auricle skin. Results Of the secondary middle ear cholesteatoma tissue samples, 6.7% were positive for CCL27 expression, whereas 33.3% of the normal auricle skin samples were positive for CCL27 expression. CCL27 was expressed less commonly in the former, and there was a significant difference in the rate of expression between the two groups(P=0.021). Conclusion The lower expression of CCL27 may be correlated with the hyperproliferative nature of the secondary middle ear cholesteatoma epithelium. CCL27 may play a significant role in the development of secondary middle ear cholesteatoma.

Key words: Immunohistochemistry, CCL27, Secondary middle ear cholesteatoma

CLC Number: 

  • R764.21
[1] Habesoglu TE, Balak N, Habesoglu M, et al. Intracranial cholesteatoma: a case report and review[J]. J Emerg Med, 2007, 32(4): 375-379.
[2] Olszewska E, Wagner M, Bernal-Sprekelsen M, et al. Etiopathogenesis of cholesteatoma[J]. Eur Arch Otorhinolaryngol, 2004, 261(1): 6-24.
[3] Quaranta N, Cassano M, Quaranta A. Facial paralysis associated with cholesteatoma: a review of 13 cases[J]. Otol Neurotol, 2007, 28(3): 405-407.
[4] Migirov L, Bendet E, Kronenberg J. Cholesteatoma invasion into the internal auditory canal[J]. Eur Arch Otorhinolaryngol, 2009, 266(5): 657-662.
[5] Morales J, Homey B, Vicari AP, et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells[J]. Proc Natl Acad Sci U S A, 1999, 96(25): 14470-14475.
[6] Riis JL, Johansen C, Vestergaard C, et al. CCL27 expression is regulated by both p38 MAPK and IKKbeta signalling pathways[J]. Cytokine, 2011, 56(3): 699-707.
[7] Homey B, Alenius H, Muller A, et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation[J]. Nat Med, 2002, 8(2): 157-165.
[8] Inokuma D, Abe R, Fujita Y, et al. CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytes[J]. Stem Cells, 2006, 24(12): 2810-2816.
[9] Pivarcsi A, Muller A, Hippe A, et al. Tumor immune escape by the loss of homeostatic chemokine expression[J]. Proc Natl Acad Sci U S A, 2007, 104(48): 19055-19060.
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