短期视网膜静脉阻塞抗VEGF治疗后黄斑区形态结构分析

doi:10.6040/j.issn.1673-3770.0.2017.515

Abstract

Abstract: Objective

To observe the morphological changes in the macular area in patients with macular edema secondary to retinal vein occlusion after intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs, using optical coherence tomography (OCT).

Methods

Fifty-six patients with retinal vein occlusion complicated with macular edema were randomly selected from the clinic. An intravitreal injection with 0.05ml of an anti-VEGF drug was administered. OCT was performed before and 7 days after the intervention. The relationship between the best corrected visual acuity, neuroepithelial effusion, external membrane, ellipsoidal band, and choroidal thickness was assessed.

Results

The best corrected visual acuity improved significantly from 0.89±0.52 to 0.56±0.46. The neuroepithelial effusion decreased from 66% to 29%; the structural integrity of the external membrane and ellipsoidal zone significantly improved from 0.88±0.79 and 0.86±0.72 to 0.30±0.54 and 0.21±0.41, respectively. The choroid thickness did not change significantly with preoperative short-term treatment (318.18±47.42) or postoperatively (320.54±45.55).

Conclusion

Patients with retinal vein occlusion secondary to macular edema with short-term morphological changes in the macular area showed improvement in visual acuity after the injection of anti-VEGF drugs, with no significant effect on the choroid.

Key words: Retinal vein occlusion, Macular edema, Anti-VEGF, Retinal micro-structural changes

CLC Number:

R774

Keyang HAN,Beibei YU,Bojun ZHAO. Morphological structure analysis of the macular area after anti-VEGF treatment for short-term retinal vein occlusion[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 129-131.

Figures/Tables 2

Table 1

Table 2

References 8

1	Rouvas A , Petrou P , Ntouraki A , et al . Intravitreal ranibizumab (Lucentis) for branch retinal vein occlusion-induced macular edema: nine-month results of a prospective study[J]. Retina (Philadelphia, Pa ), 2010, 30(6): 893-902. doi:10.1097/IAE.0b013e3181cd4894 . doi: 10.1097/IAE.0b013e3181cd4894
2	刘萍, 朱小华 . 可溶性血管内皮生长因子受体-1、2及其配体等因素在视网膜分支静脉阻塞黄斑水肿中的作用[J]. 山西医科大学学报, 2018, 49(12): 1505-1509. doi:10.13753/j.issn.1007-6611.2018.12.021 . doi: 10.13753/j.issn.1007-6611.2018.12.021
3	Suzuki Y , Nakazawa M , Suzuki K , et al . Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion[J]. Jpn J Ophthalmol, 2011, 55(3): 256-263. doi:10.1007/s10384-011-0004-8 . doi: 10.1007/s10384-011-0004-8
4	陈露, 李明新 . 玻璃体内注射雷珠单抗与康柏西普对视网膜静脉阻塞继发黄斑囊样水肿的疗效比较[J]. 中国眼耳鼻喉科杂志, 2019, 19(1): 26-30. doi:10.14166/j.issn.1671-2420.2019.01.010 . doi: 10.14166/j.issn.1671-2420.2019.01.010
5	张敏, 朱健华, 冯浩, 等 . 视网膜静脉阻塞合并黄斑水肿患者黄斑区微结构改变与视力的相关性分析[J]. 眼科新进展, 2016, 36(11): 1061-1064. doi:10.13389/j.cnki. rao. 2016.0283 . doi: 10.13389/j.cnki. rao. 2016.0283
6	杜玉芹 . 视网膜静脉阻塞治疗前后脉络膜厚度变化的分析[D]. 天津: 天津医科大学, 2016.
7	唐芬 . 黄斑水肿患者黄斑中心凹下脉络膜厚度的观察[D]. 长沙: 中南大学, 2014.
8	徐冲，冯超，吴建华 .OCTA在雷珠单抗抗体治疗视网膜分支静脉阻塞合并黄斑水肿视力预测的应用分析[J].临床眼科杂志，2018，26（5）：390-393. doi:10.3969/j.issn.1006-8422.2018.05.002 . doi: 10.3969/j.issn.1006-8422.2018.05.002

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	BCVA（LogMAR）	神经上皮层下积液（%）	外界膜	椭圆体带	脉络膜厚度（μm）
治疗前	0.89±0.52	66%	0.88±0.79	0.86±0.72	318.18±47.42
治疗后	0.56±0.46	29%	0.30±0.54	0.21±0.41	320.52±45.55
P	＜ 0.001	-	＜ 0.001	＜ 0.001	0.621
r	7.599	-	6.024	7.156	-0.497

用药		疗效		n	P
用药		治愈	未愈	n	P
BCVA	康博西普	20	7	27	0.057
BCVA	雷珠单抗	27	2	29	0.057
神经上皮层下积液	康博西普	12	8	20	0.520
神经上皮层下积液	雷珠单抗	10	8	18	0.520
外界膜	康博西普	16	1	17	0.225
外界膜	雷珠单抗	32	5	37	0.225
椭圆体带	康博西普	16	2	18	0.669
椭圆体带	雷珠单抗	16	2	18	0.669

Morphological structure analysis of the macular area after anti-VEGF treatment for short-term retinal vein occlusion

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