Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (6): 64-67.doi: 10.6040/j.issn.1673-3770.0.2018.465

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The expression and significance of metastasis suppressor 1 protein in tongue squamous cell carcinoma

JIANG Ningning1, WANG Penglai1, YUAN Changyong1, HUANG Xiaofeng2, JIANG Changwei1, LIU Zongxiang1,SUN Tiezhong1   

  1. Department of Pathology, Affiliated Stomatological Hospital of Nanjing University, Nanjing 210008, Jiangsu, China
  • Published:2019-12-23

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Abstract: Objective To compare the expression of metastasis suppressor 1(MTSS1)protein in tongue squamous cell carcinoma(TSCC)and normal tongue mucosa. Methods The expression of MTSS1 was analyzed in TSCC and normal tongue mucosa using immunohistochemical staining. Single-factor analysis was used to study the relationship between MTSS1 expression and clinicopathological factors. Results The expression of MTSS1 was lower in TSCC than in normal tongue mucosa(20 cases each). The expression of MTSS1 was higher in cases with positive lymph node metastasis(34 cases)than those negative for lymph node metastasis(46 cases). Furthermore, the expression of MTSS1 was higher in cases with higher clinical stage(37 cases)than in those with lower clinical stage(43 cases). Conclusion The decrease of MTSS1 expression may be associated with infiltration and metastasis of TSCC. MTSS1 may inhibit the occurrence and development of TSCC and play an important role in the early development of TSCC.

Key words: Metastasis suppressor 1, Tongue squamous cell carcinoma, Immunohistochemistry, Metastasis, Protein expression

CLC Number: 

  • R766.49
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