Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 1-6.doi: 10.6040/j.issn.1673-3770.0.2020.087

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Analysis of distant metastasis and prognosis of adenoid cystic carcinoma of the external auditory canal

WANG Yingying, ZHOU Han, DONG Weida, XING Guangqian, CHEN Zhibin, ZHANG Qingzhao, ZHANG Liqing   

  1. Department of Otolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nangjing 210029, Jiangsu, China
  • Published:2021-02-01

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Abstract: Objective This study aimed to investigate the risk factors of distant metastasis of adenoid cystic carcinoma of the external auditory canal and its influence on prognosis. Methods We performed a retrospective analysis of the clinical data and follow-up information of 22 patients who underwent radical surgeries and were diagnosed with adenoid cystic carcinoma of the external auditory canal by pathology. They were admitted to the First Affiliated Hospital of Nanjing Medical University from June 2007 to March 2019. The risk factors of distant metastasis and their influence on prognosis were analyzed by univariate and multivariate analyses. Results The rate of distant metastasis in this group was 40.9%, and the incidence of lung metastasis was the highest(66.7%). Univariate analysis showed that positive surgical margin and lymphatic metastasis during the operation were related to distant metastasis of adenoid cystic carcinoma of external auditory canal(P<0.05). Multivariate regression analysis showed that positive surgical margin and lymphatic metastasis were significantly associated with distant metastasis(P<0.05). The 5-year and 10-year overall survival rates of patients with adenoid cystic carcinoma of the external auditory canal who developed distant metastasis were 44.4% and 16.7%, respectively, while those without distant metastasis had 100% 5-year and 10-year survival rates. The difference was statistically significant(P<0.05). Conclusion Adenoid cystic carcinoma of the external auditory canal has a higher rate of distant metastasis, with predominant lung metastasis. Positive surgical margin and lymphatic metastasis were were independent risk factors for distant metastasis, which is an important indicator affecting the prognosis of patients with the tumor.

Key words: Adenoid cystic carcinoma, External auditory canal, Distant metastasis, Prognosis

CLC Number: 

  • R739.61
[1] International Head and Neck Scientific Group. Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: a collective international review[J]. J Laryngol Otol, 2016, 130(12): 1093-1097. doi:10.1017/s0022215116009373.
[2] Lee BJ, Bae SC, Lee JH, et al. A case of basal cell carcinoma of external auditory canal[J]. Korean J Audiol, 2012, 16(2): 91. doi:10.7874/kja.2012.16.2.91.
[3] Amit M, Na'ara S, Trejo-Leider L, et al. Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: an international collaborative study[J]. Head Neck, 2017, 39(5): 1008-1014. doi:10.1002/hed.24740.
[4] Unsal AA, Chung SY, Zhou AH, et al. Sinonasal adenoid cystic carcinoma: a population-based analysis of 694 cases[J]. Int Forum Allergy Rhinol, 2017, 7(3): 312-320. doi:10.1002/alr.21875.
[5] Subramaniam T, Lennon P, O'Neill JP. Ongoing challenges in the treatment of adenoid cystic carcinoma of the head and neck[J]. Ir J Med Sci, 2015, 184(3): 583-590. doi:10.1007/s11845-015-1298-1.
[6] Zhang Yibo, Liu Hongyan, Wu Qianru, et al. Predictors of distant metastasis and survival in adenoid cystic carcinoma of the external auditory canal[J]. Otol Neurotol, 2019, 40(10):e1006-e1011. doi: 10.1097/MAO.0000000000002391.
[7] Bonaparte JP, Trites J, Hart R, et al. Survival when treating adenoid cystic carcinoma of the external auditory canal: Quantitative assessment of case reports[J]. Journal of Otolaryngology-Head and Neck Surgery, 2009, 38(4): 468-476.
[8] Amit M, Binenbaum Y, Sharma K, et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study[J]. Head Neck, 2014, 36(7): 998-1004. doi:10.1002/hed.23405.
[9] Gao M, Hao Y, Huang MX, et al. Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma[J]. Int J Oral Maxillofac Surg, 2013, 42(8): 923-928. doi:10.1016/j.ijom.2013.04.006.
[10] 高燕, 杨慧, 陈飞, 等. 外耳道腺样囊性癌的临床诊治分析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(21): 1660-1664. doi:10.13201/j.issn.1001-1781.2018.21.013. GAO Yan, YANG Hui, CHEN Fei, et al. Clinical diagnosis and treatment of adenoid cystic carcinoma of the external auditory canal[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(21): 1660-1664. doi:10.13201/j.issn.1001-1781.2018.21.013.
[11] 冯剑, 周涵, 宋圣花, 等. 鼻腔鼻窦腺样囊性癌15例临床分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 87-91. doi:10.6040/j.issn.1673-3770.0.2018.545. FENG Jian, ZHOU Han, SONG Shenghua, et al. Clinical analysis of 15 cases of adenoid cystic carcinoma in the paranasal sinuses and nasal cavity[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 87-91.doi:10.6040/j.issn.1673-3770.0.2018.545.
[12] Girelli L, Locati L, Galeone C, et al. Lung metastasectomy in adenoid cystic cancer: Is it worth it?[J]. Oral Oncol, 2017, 65: 114-118. doi:10.1016/j.oraloncology.2016.10.018.
[13] Vishnu Prasad, Vijendra SS, Raghavendra A R. Adenoid cystic carcinoma- a rare differential diagnosis for a mass in the external auditory canal[J]. J Clin Diagn Res. 2015,9(1):MD01-2. doi: 10.7860/JCDR/2015/10374.5369.
[14] Liu HY, Zhang YB, Zhang T, et al. Correlation between the pathology and clinical presentations in patients with adenoid cystic carcinoma of the external auditory canal[J]. Head Neck, 2017,39(12): 2444-2449. doi:10.1002/hed.24915.
[15] Ebelhar AE, West DS, Aouad RK. Ceruminous adenoid cystic carcinoma of external auditory canal[J]. Int Adv Otol, 2017, 13(2): 292-294. doi:10.5152/iao.2017.3929.
[16] International Head and Neck Scientific Group. Cervical lymph node metastasis in adenoid cystic carcinoma of the major salivary glands[J]. J Laryngol Otol, 2017, 131(2): 96-105. doi:10.1017/s0022215116009749.
[17] Dillon PM, Chakraborty S, Moskaluk CA, et al. Adenoid cystic carcinoma: a review of recent advances, molecular targets, and clinical trials[J]. Head Neck, 2016, 38(4): 620-627. doi:10.1002/hed.23925. doi: 10.1093/jrr/rrz010.
[18] Takuya Nagano, Ryo-Ichi Yoshimura, Mio Kojima, et al. Outcomes of radiotherapy in advanced external auditory canal cancer[J]. Journal of radiation research, 2019, 60(3):380-386.
[19] Holliday E, Bhattasali O, Kies MS, et al. Postoperative intensity-modulated proton therapy for head and neck adenoid cystic carcinoma[J]. Int J Part Ther,2016, 2(4):533-543. doi:10.14338/ijpt-15-00032.1.
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