Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (6): 52-58.doi: 10.6040/j.issn.1673-3770.0.2021.110

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Early clinical observation of corneal densitometry after SMILE combined with rapid corneal cross-linking

ZHANG Ying, LEI Yulin, MA Zhixing, YANG Xinghua, ZHANG Jing, HOU Jie   

  1. Jinan Mingshui Eye Hospital, Jinan 250200, Shandong, China
  • Published:2021-12-10

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Abstract: Objective To study the effect of small incision lenticule extraction combined with rapid corneal collagen crosslinking(SMILE Xtra)on corneal densitometry(CD). Methods Seventy-eight patients with myopia and myopic astigmatism were collected during March 2017 and July 2019 in Jinan Mingshui Eye Hospital. The right eye data(78 eyes)were included for analysis.They were divided into two groups: SMILE Xtra(39 patients,39 eyes)and SMILE alone(39 patients,39eyes). CD data of two groups were measured by the pentacam system preoperatively and postperatively at 3 months. According to the software analysis, the average CD data of three concentric radial zones centered on the apex of the cornea(0-2 mm, 2-6 mm, 6-10 mm diameters)were applied, and three layers were defined according to different corneal depths(the anterior 120 μm as the 1st layer, the posterior 60 μm as the 3rd layer, and the center part between them as the 2nd layer). Results UCVA of 78 eyes(100%)in both groups achieved the expected corrected visual acuity postperatively at 3 months. The overall CD data of SMILE Xtra in the central two zones(0-2 mm and 2-6 mm diameter of cornea)were significantly higher than that before surgery(P<0.001). The value of the first 120μm layer was increased more than that of the other two layers.There was a significant difference in the CD data of SMILE between the preoperative and postoperative(P<0.05). There was a significant difference in the CD data of central corneal tissue and posterior 60 μm before and after operation(P< 0.05). In SMILE Xtra group, the CD data of the three zones(0-2 mm, 2-6 mm, 6-10 mm)and the anterior 120μm were higher than that of SMILE group postperatively at 3 months.The difference was statistically significant(P<0.05).There was no significant correlation between the change of CD data and the change of spherical equivalent, central corneal thickness, corneal curvature and corneal epithelial thickness(P>0.05), but negative correlation was found with age(r=-0.542, P=0.01). Conclusion In the early postoperative period, CD data increased and the corneal transparency decreased after SMILE Xtra, but only changed within the surgical area.

Key words: Femtosecond laser, Lenses, Collagen crosslinking, Corneal densitometry, Myopia

CLC Number: 

  • R779
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