Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (6): 70-76.doi: 10.6040/j.issn.1673-3770.0.2021.009

Previous Articles     Next Articles

Analysis of factors related to the severity of persistent idiopathic tinnitus

ZHOU Lamei1, JIANG Wen2,3, LIU Wen2, QIAO Yuehua2,3   

  1. 1. Graduate School, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China;
    2. Department of Otorhinolaryngology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China;
    3. Artificial Hearing Engineering Laboratory, Xuzhou Medical University, Xuzhou 221002, Jiangsu, China
  • Published:2021-12-10

PDF (PC)

599

Abstract: Objective To analyze factors related to the severity of persistent idiopathic subjective tinnitus. Methods The general data, medical history, audiological results, tinnitus matching test results, tinnitus disability scale score, Pittsburgh Sleep Quality Index score, and self-rating anxiety scale score were analyzed in 870 patients with persistent idiopathic subjective tinnitus. The multivariate Logistic regression analysis was performed to elucidate factors related to the severity of tinnitus. Results (1)There were significant differences in sex(P<0.001), age(P=0.010), tinnitus frequency(P=0.005), hearing loss(P=0.037), anxiety degree(P<0.001)and sleep status(P<0.001)in THI classification. (2)There was no significant difference in course(P=0.053), side(P=0.437)and tone loudness(P=0.120)in THI classification. Conclusion The degree of idiopathic tinnitus in female patients is more serious than that in men; low frequency is more disturbing than high frequency; anxiety degree and sleep status are the factors affecting the severity of tinnitus, while the course of disease, lateral classification and tinnitus main tone loudness are not the factors affecting the severity of idiopathic tinnitus.

Key words: Idiopathic tinnitus, Severity, Related factors, Tinnitus handicap inventory scale, Hearing loss

CLC Number: 

  • R765.21
[1] 徐霞, 卜行宽, 邢光前, 等. 江苏地区老年人主观性耳鸣的流行病学调查[J]. 中华老年医学杂志, 2006, 25(7): 548-550. doi:10.3760/j: issn: 0254-9026.2006.07.025. XU Xia, BU Xingkuan, XING Guangqian, et al. An epidemiologic study on tinnitus in aged population of Jiangsu Province[J]. Chin J Geriatr, 2006, 25(7): 548-550. doi:10.3760/j: issn: 0254-9026.2006.07.025.
[2] Langguth B, Kreuzer PM, Kleinjung T, et al. Tinnitus: causes and clinical management[J]. Lancet Neurol, 2013, 12(9): 920-930. doi:10.1016/S1474-4422(13)70160-1.
[3] 杨静, 周慧芳, 杨东. 耳鸣响度、听力下降与耳鸣严重程度的关系研究[J]. 临床耳鼻咽喉头颈外科杂志, 2013,27(10): 458-460,464. doi:10.13201/j.issn.1001-1781.2013.10.007. YANG Jing, ZHOU Huifang, YANG Dong. To analyse the impact of tinnitus loudness and hearing loss on the life of tinnitus patient[J]. J Clin Otorhinolaryngol Head Neck Surg, 2013,27(10): 458-460,464. doi:10.13201/j.issn.1001-1781.2013.10.007.
[4] Holmes S, Padgham ND. “Ringing in the ears”: narrative review of tinnitus and its impact[J]. Biol Res Nurs, 2011, 13(1): 97-108. doi:10.1177/1099800410382290.
[5] Schaaf H, Eipp C, Deubner R, et al. Psychosocial aspects of coping with tinnitus and psoriasis patients. A comparative study of suicidal tendencies, anxiety and depression[J]. HNO, 2009, 57(1): 57-63. doi:10.1007/s00106-008-1800-4.
[6] Newman CW, Jacobson GP, Spitzer JB. Development of the tinnitus handicap inventory[J]. Arch Otolaryngol Head Neck Surg, 1996, 122(2): 143-148. doi:10.1001/archotol.1996.01890140029007.
[7] 潘滔, Richard Tyler, 宋昱, 等. 耳鸣对患者日常影响调查及耳鸣活动问卷的信度检验[J]. 中国耳鼻咽喉头颈外科, 2011,18(12): 667-670. doi:10.16066/j.1672-7002.2011.12.016. PAN Tao, TYLER R, SONG Yu, et al. Investigation of the influence of tinnitus to patients in their daily life and the reliability test of tinnitus activity questionnaire[J]. Chin Arch Otolaryngol-Head Neck Surg, 2011,18(12): 667-670. doi:10.16066/j.1672-7002.2011.12.016.
[8] 路桃影, 李艳, 夏萍, 等. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学, 2014,43(3): 260-263. doi: 10.3969/j.issn.1671-8348.2014.03.002. LU Taoying, LI Yan, XIA Ping, et al. Analysis on reliability and validity of the Pittsburgh sleep quality index[J]. Chongqing Med, 2014,43(3): 260-263. doi: 10.3969/j.issn.1671-8348.2014.03.002.
[9] 徐建乐, 郑芸, 孟照莉, 等. 耳鸣严重程度与焦虑的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2012, 26(16): 729-732. doi:10.13201/j.issn.1001-1781.2012.16.012. XU Jianle, ZHENG Yun, MENG Zhaoli, et al. The relationship between tinnitus severity and anxiety[J]. J Clin Otorhinolaryngol Head Neck Surg, 2012, 26(16): 729-732. doi: 10.13201/j.issn.1001-1781.2012.16.012.
[10] 何静, 蒋斌, 梅志刚. 中枢神经可塑性变化与耳鸣发生机制研究进展[J]. 中国全科医学, 2014, 17(8): 955-959. doi:10.3969/j.issn.1007-9572.2014.08.030. HE Jing, JIANG Bin, MEI Zhigang. Plasticity changes in central nervous system and occurrence of tinnitus: research progress[J]. Chin Gen Pract, 2014, 17(8): 955-959. doi:10.3969/j.issn.1007-9572.2014.08.030.
[11] Olusanya BO, Davis AC, Hoffman HJ. Hearing loss: rising prevalence and impact published correction appears in Bull World Health Organ. 2020 Feb 1;98(2):148[J]. Bull World Health Organ, 2019, 97(10): 646-646A. doi: 10.2471/BLT.19.224683.
[12] McCormack A, Edmondson-Jones M, Fortnum H, et al. The prevalence of tinnitus and the relationship with neuroticism in a middle-aged UK population[J]. J Psychosom Res. 2014,76(1): 56-60. doi: 10.1016/j.jpsychores.2013.08.018.
[13] 陈秀兰, 秦兆冰. 性别、年龄、听力损失程度与耳鸣严重程度的关系探讨[J]. 听力学及言语疾病杂志, 2012,20(1): 26-28. doi: 10.3969/j.issn.1006-7299.2012.01.008. CHEN Xiulan, QIN Zhaobing. The impact of gender, age and hearing loss on the THI scores of patients with tinnitus[J]. J Audiol Speech Pathol, 2012,20(1): 26-28. doi: 10.3969/j.issn.1006-7299.2012.01.008.
[14] 赖仁淙, 马鑫. 耳鸣观念的文艺复兴[J]. 中华耳科学杂志, 2016, 14(2): 140-144. doi: 10.3969/j.issn.1672-2922.2016.02.002. Jen-Tsung LAI, MA Xin. Renaissance of tinnitus management [J]. Chin J Otol, 2016, 14(2): 140-144. doi: 10.3969/j.issn.1672-2922.2016.02.002.
[15] Al-Mana D, Ceranic B, Djahanbakhch O, et al. Hormones and the auditory system: a review of physiology and pathophysiology[J]. Neuroscience, 2008,153(4): 881-900. doi: 10.1016/j.neuroscience.2008.02.077.
[16] 俞晴, 宋为明, 马芙蓉, 等. 186例耳鸣患者的临床特征研究[J]. 中华耳科学杂志, 2007, 5(3): 239-243. doi:10.3969/j.issn.1672-2922. 2007.03.003. YU Qing, SONG Weiming, MA Furong, et al. Characteristics of tinnitus: an investigation of 186 patients[J]. Chin J Otol, 2007,(3), 5: 239-243. doi:10.3969/j.issn.1672-2922. 2007.03.003.
[17] 徐建乐, 郑芸, 孟照莉, 等. 耳鸣严重程度与焦虑的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2012,26(16): 729-732. doi:10.13201/j.issn.1001-1781.2012.16.012. XU Jianle, ZHENG Yun, MENG Zhaoli, et al. The relationship between tinnitus severity and anxiety[J]. J Clin Otorhinolaryngol Head Neck Surg, 2012,26(16): 729-732. doi:10.13201/j.issn.1001-1781.2012.16.012.
[18] Olsen US, Lello E, Nagaraj VS, et al. Factors affecting severity of tinnitus-a follow-up study of tinnitus subjects at an Ear Nose Throat clinic in Sweden[J]. Int Tinnitus J, 2013, 18(2): 115-121. doi:10.5935/0946-5448.20130013.
[19] 齐思涵, 秦兆冰, 陈秀兰, 等. 影响慢性主观性耳鸣严重程度的相关因素分析[J]. 听力学及言语疾病杂志, 2014,22(4): 367-370. doi:10.3969j/.issn.10067299.2014.04.0. QI Sihan, QIN Zhaobing, CHEN Xiulan, et al. The correlation factors of the severity of chronic subjective tinnitus[J]. J Audiol Speech Pathol, 2014,22(4): 367-370. doi:10.3969j/.issn.10067299.2014.04.0.
[20] Baguley D, McFerran D, Hall D. Tinnitus[J]. Lancet, 2013, 382(9904): 1600-1607. doi:10.1016/s0140-6736(13)60142-7.
[21] Zhang JJ, Zhang Z, Huang SJ, et al. Differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus[J]. Neural Plast, 2020, 2020: 1-12. doi:10.1155/2020/5285362.
[22] 王梦琳, 宋昱, 马芙蓉. 纹状体参与耳鸣神经调控的研究进展[J]. 中华耳科学杂志, 2020,18(2): 363-366. doi: 10.3969/j.issn.1672-2922.2020.02.028. WANG Menglin, SONG Yu, MA Furong. Advances of research on striatum involvement in tinnitus neuromodulation[J]. Chin J Otol, 2020,18(2): 363-366. doi: 10.3969/j.issn.1672-2922.2020.02.028.
[23] Jastreboff PJ. Phantom auditory perception(tinnitus): mechanisms of generation and perception[J]. Neurosci Res, 1990, 8(4): 221-254. doi:10.1016/0168-0102(90)90031-9.
[24] 陈秀兰, 宋凡, 秦兆冰, 等. 耳鸣严重程度与焦虑、抑郁及人格特征的相关性[J]. 听力学及言语疾病杂志,2021, 29(4):1-3. doi:10.3969/j.issn.1006-7299.2021.04.020.
[25] 宋勇莉, 齐柳, 陈阳, 等. 慢性耳鸣患者合并焦虑和抑郁影响因素的分析[J]. 听力学及言语疾病杂志, 2021,29(4): 398-402. doi:10.3969/j.issn.1006-7299.2021.04.009. SONG Yongli, QI Liu, CHEN Yang, et al. Influencing factors of anxiety and depression in patients with chronic tinnitus[J]. J Audiol Speech Pathol, 2021,29(4): 398-402. doi:10.3969/j.issn.1006-7299.2021.04.009.
[26] 余力生, 马鑫. 耳鸣的代偿与失代偿[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(8): 630-633. doi: 10.3760/cma.j.issn.1673-0860.2017.08.019. YU Lisheng, MA Xin. Compensation and decompensation of tinnitus[J]. Chinese JOurnal of Otorhinolaryngology Head and Neck Surgery, 2017, 52(8): 630-633. doi: 10.3760/cma.j.issn.1673-0860.2017.08.019.
[27] 钟萍, 卢兢哲, 郑芸, 等. 基于医师疗法理念调整生活方式对265例耳鸣患者的疗效观察[J]. 中国听力语言康复科学杂志, 2018,16(6): 430-432. doi: 10.3969/j.issn.1672-4933.2018.06.007. ZHONG Ping, LU Jingzhe, ZHENG Yun, et al. A short-term treatment efficacy study of 265 tinnitus patients intervened with lifestyle adjustment based on yi Shi therapy(YST)principles[J]. Chin Sci J Hear Speech Rehabilitation, 2018,16(6): 430-432. doi: 10.3969/j.issn.1672-4933.2018.06.007.
[1] WANG Min, LIU Hao, JIANG Luhan, TAN Liyue, LI Wen, FU Xiaolong. Packaging of AAV-ie-Tnfaip8l2 and its effect on improving auditory function in Tnfaip8l2-/- mice [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 7-15.
[2] WANG Menghui, LI Ao, WEI Hao, JIANG Yue, WU Xingguang, LI Luxi, QIAN Xiaoyun. Multiple mechanisms and clinical warning signs of deafness caused by hepatitis B virus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 110-114.
[3] WANG Kaijian, WANG Wei, CHEN Xuesheng, FAN Chunsun, HE Yingying, HUANG Dongling, QIAN Cunhui, DING Shujun. Correlation between neutrophil-to-lymphocyte ratio with hearing loss and audiometric thresholds in adults: a cross-sectional study based on NHANES [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 18-28.
[4] TAO Duoduo, SHI Bin, ZHAO Yunshu, LI Yonggang, LIU Jisheng. Preliminary study on neurotransmitter levels in the anterior cingulate cortex and their relationship with hearing levels in patients with age-related hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 31-39.
[5] ZHENG Zehao, WEI Jiali, LIU Jiatao, ZHOU Yuqi, SUN Wenting, LI Yuxuan, BAI Peng. Evaluation of the efficacy and safety of site-specific acupuncture for the treatment of sudden hearing loss: a systematic review and network Meta-analysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 114-127.
[6] LI Jie, SU Weina, LIN Qian, ZHANG Qishu, HOU Cheng, YANG Zhenjiao, XIANG Lili. Genetic analysis of MARVELD2 gene variants in two deafness cases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 128-134.
[7] DONG Lingkang, YU Dongzhen. Trends and projections of the burden of age-related hearing loss in China from 1990 to 2021 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 61-69.
[8] ZHANG Lixia, LI Lin. Research on screening the key genes of age-related hearing loss by GEO database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 104-114.
[9] LIN Yushan, LU Biaoqing. Personalized use of batroxobin in the treatment of sudden sensorineural hearing loss with full frequency decline [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 115-121.
[10] WANG Xin, YUAN Jingjing, HAO Pengpeng, YAN Zhanfeng, LIU Jianhua, ZHONG Liqun, LIU Siming, WU Wei, ZHAO Xiaoyang, ZHANG Ying. Protective effect of Chinese herbal medicine on sudden sensorineural hearing loss: a retrospective analysis and network pharmacology [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 6-17.
[11] PAN Jiayu, ZHANG Chunlin. Research advances on the etiology and pathogenesis of acute low-frequency sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 126-131.
[12] GUO Xiang, MA Yongqiang, YI Haijin. Current status and advances in magnetic resonance imaging in sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 140-144.
[13] CHEN Danping, HE Zijian, YU Youjun, ZHOU Xiaowei. Analysis of the efficacy and prognostic factors of hospitalized cases of children with sudden sensorineural hearing loss for ten years [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 16-22.
[14] CAO Ying, QIU Yue, CHEN Zhibin, FEI Bing, LI Dong, ZHANG Xiaofeng,WANG Hui,KANG Xinle, WANG Haixu,HUAI De,LI Xiuting, SHU Mingyang. Comparative analysis of speech recognition ability before and after treatment of intractable sudden deafness using retroaural injection of ganglioside and intratympanic injection of methylprednisolone [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 15-21.
[15] LIANG Junjie, ZHANG Jiajia, ZHANG Linjing, MENG Yan, LI Yang, BAI Peng. Sudden sensorineural hearing loss combined with hand, foot and mouth disease treated by integrated traditional Chinese and western medicine: a case study and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 91-95.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd