Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 83-87.doi: 10.6040/j.issn.1673-3770.0.2022.528

• 论著 • Previous Articles     Next Articles

Association of macular retinoschisis severity with choroidal parameters in patients with high myopia

YOU Ran, GUO Xiaoxiao, WANG Wei, CHEN Xi, WANG Yanling   

  1. Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Published:2023-05-24

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Abstract: Objective This study aimed to evaluate the characteristics and clinical significance of macular choroidal parameters according to the different severity classifications of retinoschisis in patients with high myopia. Methods This cross-sectional study included 74 patients(74 eyes)diagnosed with high myopia of grades T0~T3, according to the atrophy-traction-neovascularization(ATN)classification, from January 2019 to March 2022 at the Ophthalmology Department of the Beijing Friendship Hospital, which is affiliated with the Capital Medical University. Of these patients, there were 20 male(20 eyes)and 54 female(54 eyes)patients with a mean age of(64.3±11.2)years and axial length(AL)of 29.2±2.78 mm. All patients underwent enhanced depth imaging optical coherence tomography. They were then classified as having T0, T1, T2, or T3 grades(n=20, 23, 18, and 13 eyes, respectively)according to the severity of their lesions based on the ATN classification. The choroidal thickness of multiple parts of the fovea was measured, and the macular choroidal volume(MCV)was calculated using the MATLAB software. Correlation analysis of the different parameters was performed. Differences between the groups were compared using univariate and multivariate analyses. Results The mean MCV of the patients in the T0, T1, T2, and T3 groups was(4.6±2.3)mm3,(3.1±1.2)mm3,(2.9±1.3)mm3, and(2.1±1.1)mm3, respectively, and the differences between these groups were statistically significant(P=0.006). The best corrected visual acuity of patients in the T1-T3 groups was significantly lower than that of patients in the T0 group. The AL and absolute value of the spherical equivalent were significantly higher(P<0.05), while the subfoveal choroidal thickness(SFCT)was significantly lower(P<0.05)than those in the T0 group. Differences in the value of the spherical equivalent between the T1 and T3 groups and between the T2 and T3 groups and in SFCT and MCV between the T1 and T2 groups and between the T1 and T3 groups were AL- and age-dependent. Meanwhile, differences in SFCT and MCV between the T2 and T3 groups were independent of AL and age. Conclusion The study revealed a gradual decrease in MCV associated with the increasing severity of retinoschisis in patients with high myopia. The change in MCV was affected by AL, age, and other factors.

Key words: High myopia, Retinoschisis, Macular choroidal volume, Atrophy-traction-neovascularization classification, Optical coherence tomography

CLC Number: 

  • R774.5
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