Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 16-25.doi: 10.6040/j.issn.1673-3770.0.2022.351

• Original Article • Previous Articles     Next Articles

Clinical observation of the effect of infiltrating Biprofen Gelatin Sponge after functional endoscopic sinus surgery

WANG Lixue1, ZENG Yi2, WANG Lixin2, PENG Xianbing2   

  1. 1. Department of Otorhinolaryngology, Postgraduate Training Base of Jinzhou Medical University (Shiyan Renmin Hospital), Shiyan 442000, Hubei, China2. Department of Otorhinolaryngology, Shiyan Renmin Hospital, Shiyan 442000, Hubei, China
  • Published:2023-10-13

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Abstract: Objective To investigate the efficacy and safety of gelatin sponge packing with infiltrating Biprofen spray in patients with CRSwNP after nasal endoscopic surgery. Methods 112 patients with CRSwNP undergoing nasal endoscopic surgery were randomly divided into three groups: those receiving intraoperative packing of momethasone furoate gelatin sponge and postoperative irrigation with physiological sea water(group A), intraoperative packing of momethasone furoate gelatin sponge and postoperative irrigation with Biprofen spray(group B), and intraoperative packing of gelatin sponge of infiltrating Biprofen spray and postoperative irrigation of the postoperative cavity of Biprofen spray(group C). SNOT-22 score, Lund-Kennedy endoscopic score and vascular endothelial growth factor(VEGF)expression in vesicles were determined before the operation and at 2, 4, 8 and 12 weeks postoperatively. The differences in subjective and objective scores before and after the operation were compared among the three groups to evaluate their safety. Results a total of 93 patients completed the required 3-month follow-up. The subjective score after operation was significantly lower than before, but there was no significant difference among the follow up nodes of the three groups postoperatively. Objective endoscopic evaluation showed a statistically significant difference in 2, 4, 8 and 12 weeks after operation, and a trend of A>B=C was observed. The differences in objective immunohistochemical score was statistically significant at 12 weeks of follow-up and showed a A>B=C trend. Conclusion The intraoperative packing effect of infiltrating momethasone furoate gelatin sponge is the same as that of infiltrating Biprofen gelatin sponge, which can effectively improve the subjective symptoms of chronic sinusitis with nasal polyps after nasal endoscopic surgery, accelerate mucosal recovery and epithelialization, and VEGF expression in mucosal tissue is significantly decreased. Thus, the clinical application of infiltrating Biprofen gelatin sponge is safe.

Key words: Sinusitis, Nasal polyps, Mucous excretion enhancers, Glucocorticoids, Vascular endothelial growth factor

CLC Number: 

  • R762
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