Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (3): 116-123.doi: 10.6040/j.issn.1673-3770.0.2023.338

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Effect of matrix metalloproteinase on tissue remodeling in chronic rhinosinusitis

ZHANG Shihan, LIU Hongbing   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
  • Published:2024-06-04

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Abstract: The pathogenesis of chronic rhinosinusitis, a highly heterogeneous inflammatory disease of the sinus mucosa, is not fully understood. Tissue remodeling, which is the main factor in the pathogenesis of chronic rhinosinusitis, is characterized by features such as epithelial mucosal damage, basement membrane thickening, neovascularization, and fibroblast proliferation, aiming toward the generation and degradation disorder of extracellular matrix. Matrix metalloproteinases are one of the important enzymes that degrade extracellular matrix. Matrix metalloproteinases and tissue metalloproteinase inhibitors influence tissue remodeling by influencing extracellular matrix metabolism. Inhibition of the effects of these matrix metalloproteinases on tissue remodeling is a potential therapeutic approach. This article reviews the research progress of the effects of inhibitors of matrix metalloproteinases and tissue metalloproteinases on tissue remodeling in chronic sinusitis.

Key words: Chronic rhinosinusitis, Nasal polyps, Matrix metalloproteinase, Tissue remodeling, Tissue inhibitor of matrix metalloproteinases

CLC Number: 

  • R765.41
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