Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (3): 40-46.doi: 10.6040/j.issn.1673-3770.0.2025.267

• Original Article • Previous Articles     Next Articles

Application of electronic nasopharyngoscopy combined with narrow band imaging in traditional Chinese medicine syndrome differentiation of nasopharyngeal carcinoma

LIN Xiaoxue, LIN Baorui, LI Peishan, LU Biaoqing   

  1. Department of Otorhinolaryngology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, Guangding, China
  • Published:2026-05-22

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Abstract: Objective To investigate the correlation between local features of nasopharyngeal carcinoma(NPC)observed under electronic nasopharyngoscopy combined with narrow band imaging(NBI)and traditional Chinese medicine(TCM)syndrome patterns, providing objective imaging evidence for TCM syndrome differentiation. Methods A total of 197 patients with newly diagnosed NPC treated at Zhongshan Hospital of Traditional Chinese Medicine from May 2023 to May 2025 were enrolled and classified into four TCM syndrome types: Re Xie Fan Fei syndrome(n=49), Xue Yu Zu Luo syndrome(n=48), Tan Zhuo Jie Ju syndrome(n=70), and Zheng Xu Du Zhi syndrome(n=30). Electronic nasopharyngoscopy combined with NBI was used to observe local features including mucosal morphology, color, integrity, as well as microvascular color, density, and morphology. The correlation between these features and TCM syndrome types was analyzed. Results NPC TCM syndrome patterns showed significant associations(P<0.05)with endoscopic characteristics, including lesion border clarity, mucosal color, mucosal integrity, bleeding tendency, secretion properties, and NBI microvascular features(color, density, and morphology). Key manifestations for each syndrome type were as follows: Re Xie Fan Fei syndrome was characterized by marked mucosal congestion and purulent secretions; Xue Yu Zu Luo syndrome featured well-defined borders, absence of secretions, and NBI findings of brownish-green microvessels with dense fusion and serpentine tortuosity; Tan Zhuo Jie Ju syndrome presented with mucosal color similar to surrounding tissue and increased secretions; Zheng Xu Du Zhi syndrome was characterized by irregular borders, pale mucosa, and clear secretions. Conclusion Electronic nasopharyngoscopy combined with NBI technology can objectively reveal mucosal and microvascular alterations in NPC, providing a visual basis for TCM syndrome differentiation and guiding clinical precision treatment.

Key words: Nasopharyngeal carcinoma, Electronic nasopharyngoscopy, Narrow band imaging, Traditional Chinese medicine syndrome patterns

CLC Number: 

  • R766.3
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