Abstract: ［ABSTRACT］Objective： To discuss the diagnosis, treatment and prognosis of the primary nonHodgkin lymphoma in nose, pharynx and larynx. Methods： The clinical data of 64 primary nasal, pharyngeal and laryngeal nonHodgkin lymphomas were retrospectively reviewed. The prognostic factors of the lymphoma were evaluated. Results： Of the 64 patients, 29 had T cell lymphomas, 16 NK/T cell lymphomas, 16 B cell lymphomas and 3 unclassified lymphomas; of the 31 patients of Ann Arbor stage, 21 were stageⅡ, 11 stage Ⅲand 1 stage Ⅳ; 25 patients received chemotherapy alone, 27 chemotherapy combined with radiotherapy, and 5 radiotherapy alone. The 3year overall survival rate was 67.24%. There was no significant difference of the 3year survival rate between the chemotherapy and the chemotherapy combined with radiotherapy (P=0.0704). Univariate analysis showed that Ann Arbor classification, international prognostic index (IPI), performance state and LDH were prognostic factors. Multivariate analysis by Cox regression demonstrated that only IPI was an independent prognostic factor. Conclusion： The T cell lymphoma is the predominant type of NHL in nose, pharynx and larynx. The therapy of chemotherapy combined with radiotherapy can not improve the cure rate. IPI is an independent prognostic factor.

Key words: Laryngeal neoplasms, Lymphoma, ［KEY WORDS］Nasopharynggeal neoplasms, nonHodgkin, Diagnosis, Prognosis