Abstract: Objective To explore the efficacy of Mometasone furoate and Yupingfeng particles in adenoid hypertrophy in children. Methods A total of 90 children aged 4-10 years completed 8 weeks treatment were enrolled in a prospective and randomized controlled study. The symptoms and degree of obstruction were evaluated by nasopharyngoscopy conducted pre-treatment and 8weeks post-treatment. Subjects received Mometasone furoate nasal spray alone at a daily dose of 200 μg or combination with Yupingfeng particles by a dose of 5 g twice a day for 8 weeks. Actual data were compared between the two groups. Results With Mometasone treatment, there was an 19.5 percent reduction in total clinical symptom score, and the degree of obstruction dropped from 82.2 to 73.6 percent(P<0.01). With Mometasone and Yupingfeng particles treatment, there was a 31.7 percent reduction in total clinical symptom score, and the degree of obstruction dropped from 85.4 to 71.4 percent(P<0.01). A statistically significant incidence of upper respiratory tract infection was seen in patients treated with Mometasone furoate nasal spray and Yupingfeng particles(16.7%)as compared with Mometasone alone(44.2%). Conclusion Mometasone furoate appears to be effective in treating children with adenoid hypertrophy. In combination with Yupingfeng particles, it can reduce the incidence of upper respiratory tract infection.

Key words: Yupingfeng particles, Adenoid hypertrophy, Mometasone furoate, Treatment outcome