J Otolaryngol Ophthalmol Shandong Univ ›› 2018, Vol. 32 ›› Issue (5): 97-102.doi: 10.6040/j.issn.1673-3770.0.2018.058

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Targeted therapy for head and neck squamous cell carcinoma

WU Jing, LIU Yehai   

  1. Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Anhui Medical University, Hefei 230022, Anhui, China
  • Received:2018-05-25 Online:2018-09-20 Published:2018-09-20

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Abstract: Head and neck cancer is one of the most common tumors in the world. More than 95% of all pathological types are squamous cell carcinomas. The combination of surgery and radiotherapy and chemotherapy is the widely accepted treatment for head and neck squamous cell carcinoma(HNSCC). However, the overall survival rate is low, mainly owing to tumor recurrence and/or metastasis. Meanwhile, in recurrent or metastatic HNSCC, surgery is often difficult. Moreover, the effect of radiotherapy and chemotherapy is also poor. The discovery of targeted therapy has provided a new approach for the treatment of HNSCCs, especially those that are recurrent or metastatic. To further understand the clinical therapeutic effect of targeted therapy, this article reviews the research progress of targeted therapy for HNSCC.

Key words: Targeted therapy, Head and neck squamous cell carcinoma

CLC Number: 

  • R739.6
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