JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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WANG Li1,LU Yong-hui2   

  • Received:2005-09-30 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
  • Contact: WANG Li

Abstract: To investigate the expression of telomerase activity and human telomerase reverse transcriptase(hTERT) in the nasal polyp tissues and their significance. Method: The expression of hTERT of 40 cases of nasal polyp tissues and 10 cases of normal inferior turbinate tissues was detected by immunohistochemical staining (PV9000 twostep kit). Results: The expression of telomerase in normal inferior turbinate tissues and nasal polyp tissues was 0 and 82.5%, respectively, and the difference was significant. The expression of telomerase had no significant correlation to the tumor grade, but had close correlation to the recurrence. Conclusion: The expression of telomerase is closely related with nasal polyp progression. It could be postulated that telomerase activity could be related with the tendency of polyp to recur.

Key words: Telomerase, Polyps, Immunohistochemistry

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