山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 62-64.doi: 10.6040/j.issn.1673-3770.0.2015.167

• 论著 • 上一篇    下一篇

南京地区急性细菌性结膜炎的最新致病菌分析

赵太宏, 李中国   

  1. 南京医科大学附属南京医院 南京市第一医院眼科, 江苏 南京 210006
  • 收稿日期:2015-04-23 修回日期:2015-09-22 出版日期:2015-10-16 发布日期:2015-10-16
  • 作者简介:赵太宏,E-mail:zhao.eye@163.com

Pathogens of acute bacterial conjunctivitis in Nanjing area

ZHAO Taihong, LI Zhongguo   

  1. Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China
  • Received:2015-04-23 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

摘要: 目的 了解南京地区急性细菌性结膜炎的致病菌分布情况,为有效治疗本病提供参考。方法 选取符合纳入标准的96眼急性细菌性结膜炎的结膜囊分泌物进行病原学检测,同时予以加替沙星滴眼液滴眼,每日4次,连续治疗1周,再次取分泌物进行病原学检查,并进行对比分析。结果 86眼均成功采集结膜囊分泌物。首次病原学检测阳性率为81.25%,其中革兰阴性细菌占15.63%,以大肠埃希菌及肺炎克雷伯菌为主;而革兰阳性细菌占65.63%,其中位居前三的分别为表皮葡萄球菌50眼(52.08%),金黄色葡萄球菌7眼(7.29%),腐生葡萄球菌3眼(3.13%)。治疗1周后,患者临床症状均治愈,再次行病原学检查,仍有11眼阳性,表皮葡萄球菌7眼(8.14%),金黄色葡萄球菌4眼(4.65%),67眼(77.92%)转为阴性。结论 葡萄球菌尤其以表皮葡萄球菌为主是南京地区急性细菌性结膜炎的主要致病菌,临床治疗本病应注意合理用药。

关键词: 细菌性结膜炎, 急性, 病原学检测

Abstract: Objective To investigate the pathogenic bacteria of acute bacterial conjunctivitis in Nanjing area and to provide reference for treatment. Methods Ninety-six eyes with acute bacterial conjunctivitis were enrolled in this study. Bacterial culture was performed on secretion specimens from conjunctival sac. Meanwhile, treatment with Gatifloxacin eye drops(4 times per day, 1 week) was carried out. After treatment, secretion specimens were re-cultivated. Results Secretion specimens of 86 eyes were successfully collected and cultivated two times. The positive rate was 81.25% in the first time. The percentages of gram positive bacteria (the top three: Staphylococcus epidermidis 52.08%, Staphylococcus aureus 7.29% and Staphylococcus saprophyticus 3.13%) and Gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) in the bacteria were 65.63% and 15.63% respectively. No eye symptoms were observed after the treatment. For the second cultivation, 67 eyes(77.92%) turned to negative, 7 eyes(8.14%) were with Staphylococcus epidermidis and 4 eyes(4.65%) with Staphylococcus aureus. Conclusion The main pathogenic bacterium in acute bacterial conjunctivitis in Nanjing Area is Staphylococcus epidermidis, which should be paid attention in clinical treatment.

Key words: Acute, Bacterial conjunctivitis, Etiology detection

中图分类号: 

  • R77
[1] 惠延年. 眼科学[M]. 5版.北京:人民卫生出版社,2001:67.
[2] 张伦占. 临床治疗细菌性结膜炎124例的经验总结[J].国际眼科杂志, 2014,14(10):1908-1910. ZHANG Lunzhan. Clinical experience summary of bacterial conjunctivitis treatment in 124 cases[J]. Inter Eye Sci, 2014, 14(10):1908-1910.
[3] Hwang D G, Schanzlin D J, Rotberg M H, et al. Levofloxacin Bacterial Conjunctivitis Place. controlled Study Group. A phaseⅢ. Placebo controlled clinical trial of 0.5% levofloxacin ophthalmic solution for the treatment of bacterial conjunctivitis[J]. Br J Ophthalmol, 2003, 87:1004-1009.
[4] Hivding G. Acute bacterial conjunctivitis[J]. Acta Ophthamlol, 2008, 86(1):5-17.
[5] 姜洋,金玉梅,罗岩,等.我国急性细菌性结膜炎最新病原学分析[J].眼科新进展, 2013, 33(4): 335-337. JIANG Yang, JIN Yumei, LUO Yan, et al. Etiological analysis of acute bacterial conjunctivitis in China[J]. Recent Adva Ophthalmol, 2013, 33(4):335-337.
[6] 王玉萍,张文芳,王多春,等. 兰州地区细菌性结膜炎的致病菌分布和耐药性分析[J].中国实用眼科杂志, 2011, 29(11):1159-1161. WANG Yuping, ZHANG Wenfang, WANG Duochun, et al. Distribution and drug resistance of pathogenic bacteria in bacterial conjunctivitis in Lanzhou area[J]. Chin J Prac Ophthalmol, 2011, 29(11):1159-1161.
[7] 张立贵,仇宜解,吕秀文,等.细菌性结膜角膜炎的病原菌分析[J].中国实用眼科杂志,1996,14(11):671-673. ZHANG Ligui, QIU Yijie, LV Xiuwen, et al. Analysis of pathogenic bacteria in bacterial and keratitis[J]. Chin J Prac Ophthalmol, 1996, 14(11):671-673.
[8] 黎明,姚晓明,周青,等.新生儿急性细菌性结膜炎10年致病菌变迁[J].中国实用眼科杂志,2011,29(3):287-293. LI Ming, YAO Xiaoming, ZHOU Qing, et al. The transition of bacterial pathogens in acute neonatal conjunctivitis in recent 10 years[J]. Chin J Prac Ophthalmol, 2011, 29(3):287-293.
[9] Adebayo A, Parikh J G, McCormick S A, et al. Shifting trends in in vitro antibiotic susceptibilities for common bacterial conjunctival isolates in the last decade at the New York Eye and Ear Infirmary[J]. Graefes Arch Clin Exp Ophthalmol, 2011, 249(1):111-119.
[10] Bharathi M J, Ramakrishnan R, Shivakumar C, et al. Etiology and antibacterial susceptibility pattern of community-acquired bacterial ocular infections in a tertiary eye care hospital in south India[J]. Indian J Ophthalmol, 2010, 58(6):497-507.
[11] Nayak N, Satpathy G, Nag H L, et al. Slim e production is essential for the adherence of Staphylococcus epidermidis in implant-related infections[J]. J Hosp Infect, 2011, 77(2):153-156.
[1] 苏杰,艾昕,马春梅,杨馥宇,黄帅. 急性高眼压大鼠外侧膝状体神经元细胞自噬与凋亡的关系[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 68-71.
[2] 何丽,马鲁新,赵博军,曹素燕,王玉梅. 急性共同性内斜视的临床特点、治疗方法及长期疗效[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 89-90.
[3] 李玲,王春玲,张丽,李延忠. 阻塞性睡眠呼吸暂停低通气综合征患者手术麻醉中困难气道发生的因素预测[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 62-67.
[4] 孙莎莎,邱杰,臧传善,孙彦. 白塞病误诊为急性会厌炎两例[J]. 山东大学耳鼻喉眼学报, 2017, 31(5): 107-109.
[5] 于斌,郑青平,罗展雄,李旌,周媛媛,李中华,王磊黎,贺婵娟,石丰榕. 重组人表皮生长因子预防鼻咽癌放射性口腔黏膜炎和急性放射性皮炎的疗效观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(1): 95-99.
[6] 祝青萍, 万玉柱. 儿童急性鼻窦炎眶并发症的临床表现及治疗[J]. 山东大学耳鼻喉眼学报, 2017, 31(1): 91-94.
[7] 刘学升,李筱瑜,邓玮. 后半规管良性阵发性位置性眩晕急性发作时的临床表现[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 11-13.
[8] 李存杰,孙宇. 七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的疗效及安全性[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 75-77.
[9] 孙娟,张淑娥,杨立新. 首诊于眼科的急性淋巴细胞白血病1例[J]. 山东大学耳鼻喉眼学报, 2014, 28(3): 91-92.
[10] 王志刚,吕荣林. 颈深部间隙感染误诊为急性会厌炎1例[J]. 山东大学耳鼻喉眼学报, 2013, 27(3): 89-89.
[11] 董卫红,周 芳,毕宏生,王兴荣,杜秀娟,马先祯,俞 超 . 急性视网膜坏死综合征临床治疗42眼[J]. 山东大学耳鼻喉眼学报, 2008, 22(5): 457-459 .
[12] 赵鲁新,翟 洪,潘 洁 . 超声乳化吸除联合晶状体植入治疗急性闭角型青光眼伴白内障23例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 260-262 .
[13] 侯成杰,张庆泉,王 强,王有福 . 急性会厌炎所致的严重喉梗阻的紧急处理[J]. 山东大学耳鼻喉眼学报, 2007, 21(2): 149-150 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!