细胞焦亡的分子机制及其在头颈部鳞状细胞癌中的研究现状

doi:10.6040/j.issn.1673-3770.0.2022.179

摘要/Abstract

摘要： 癌症患者的低生存率和癌细胞耐药的高发病率让研究者们寻找更多的抵抗癌症的方式。细胞程序性死亡不仅在胚胎发育过程中起着重要作用,而且在疾病如癌症的发生、发展中起着重要作用。细胞焦亡,作为程序性死亡方式的一种,在肿瘤中的双重作用受到越来越多的关注。复习抗癌背景下细胞焦亡的分子机制,以洞察其对抵抗癌症的潜力,并介绍其在头颈部鳞状细胞癌中的相关研究。

关键词: 细胞焦亡, 头颈部鳞状细胞癌, Gasdermin介导, 半胱氨酸蛋白酶

Abstract: Poor survival rates for cancer patients have led to further research on treatments to fight the disease. Programmed cell death(PCD)plays an important role not only in embryonic development, but also in occurrence and development of cancers. Pyroptosis is a type of PCD which has been receiving increasing attention for its dual role in tumors. This paper describes the molecular mechanisms of pyroptosis in terms of anti-cancer properties and aims to gain insight into its potential for cancer resistance. We also introduce related research on head and neck squamous cell carcinoma.

Key words: Pyroptosis, Head and neck squamous cell carcinoma, Gasdermin, Caspase

中图分类号:

R739.6

杨英玲,苟浩铖,冯俊. 细胞焦亡的分子机制及其在头颈部鳞状细胞癌中的研究现状[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 160-165.

YANG Yingling, GOU Haocheng, FENG Jun. Review of pyroptosis molecular mechanism and applications in head and neck squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 160-165.

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