细胞焦亡在变应性鼻炎中的作用机制及研究进展

doi:10.6040/j.issn.1673-3770.0.2021.463

摘要/Abstract

摘要： 变应性鼻炎(AR)是由环境和遗传因素共同作用导致的鼻黏膜变应性炎症疾病,目前AR的发病率呈现每年不断升高的趋势,给人们的身心健康、生活等造成严重的影响,其主要的治疗手段包括避免接触过敏原、药物治疗和免疫治疗等,但是部分患者治疗效果并不理想,究其原因主要与其发病机制复杂多样有关。细胞焦亡是程序性细胞死亡的一种,近年来研究表明细胞焦亡通过多种途径参与了AR的发生发展,部分药物可以通过抑制细胞焦亡来治疗AR。因此,深入探索细胞焦亡对AR的调控机制可能为AR的治疗提供新思路。论文就细胞焦亡在AR中的作用机制及研究进展进行综述。

关键词: 细胞焦亡, 变应性鼻炎, 炎症小体, caspase蛋白酶, NOD样受体蛋白

Abstract: Allergic rhinitis is an allergic inflammatory disease of the nasal mucosa caused by environmental and hereditary factors. The incidence rate of allergic rhinitis is increasing every year, and this has a serious impact on people's physical and mental health. The main therapeutic methods include drug therapy and immunotherapy, but the treatment effect is not ideal in some cases. The reason is mainly due to its complicated pathogenesis is complicated. Pyroptosis is a type of programmed cell death. In the recent years, studies have shown that pyroptosis is involved in the occurrence and development of allergic rhinitis. Some drugs can treat allergic rhinitis by inhibiting pyroptosis. Therefore, further exploration of the regulatory mechanisms of pyroptosis may provide new insights for the treatment of allergic rhinitis. This article reviews the mechanisms and research progress of pyroptosis in allergic rhinitis.

Key words: Pyroptosis, Allergic rhinitis, Inflammasome, Caspase, NLRP

中图分类号:

R765

刘真,宋西成. 细胞焦亡在变应性鼻炎中的作用机制及研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 123-129.

LIU Zhen,SONG Xicheng. Mechanisms and research progress of pyroptosis in allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 123-129.

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