山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 156-162.doi: 10.6040/j.issn.1673-3770.0.2023.409
王新钰1,2,高丽芬1,2,路晖2,宋文琦2,杨钰2
WANG Xinyu1,2, GAO Lifen1,2, LU Hui2, SONG Wenqi2, YANG Yu2
摘要: 帕金森疾病是由α-突触核蛋白在神经系统中的异常沉积和多巴胺能神经的损伤引发运动迟缓、静止性震颤等运动症状的神经退行性疾病。由于视觉障碍在病程早期即可发现,视网膜的功能改变和结构改变可在帕金森疾病诊断和治疗策略中起到重要作用。综述探讨了帕金森病有关的的视网膜变化,如视网膜多巴胺能神经元数量减少,使用光学相干断层扫描测量的视网膜神经纤维层和黄斑变薄,视网膜电图中振幅降低和潜伏期缩短等解释帕金森病对视网膜的影响。本文认为帕金森患者视网膜异常可以作为早期评估帕金森病发病的潜在标志物,并有助于对患者进行疾病的分期,对于帕金森病的诊断和治疗策略具有重要意义。
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