山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (5): 14-19.doi: 10.6040/j.issn.1673-3770.1.2020.062

• 临床研究 • 上一篇    下一篇

梅尼埃病前庭功能分级的探讨

刘宇鹏,梁敏,何景春,郑贵亮,李姝娜,张青,杨军   

  1. 刘宇鹏, 梁敏, 何景春, 郑贵亮, 李姝娜, 张青, 杨军上海交通大学医学院附属新华医院 耳鼻咽喉头颈外科/上海交通大学医学院 耳科学研究所/上海市耳鼻疾病转化医学重点实验室, 上海 200092
  • 收稿日期:2020-07-07 出版日期:2020-09-20 发布日期:2020-11-17
  • 基金资助:
    上海交通大学医工交叉重点项目(ZH2018ZDA11);上海交通大学医学院附属新华医院院级临床研究培育基金项目(17CSK03,18JXO04)

A new grade of vestibular function abnormality in Menieres disease: a pilot study

To establish a new grade of vestibular function abnormality in patients with Menieres disease(MD)and to preliminarily investigate its clinical significance and correlation with the hearing stage. MethodsClinical data of patients with unilateral intractable MD hospitalized from January 2015 to December 2019 were retrospectively reviewed. All patients underwent pure-tone audiometry, cervical vestibular-evoked myogenic potential(cVEMP)testing, ocular VEMP(oVEMP)testing, the video head impulse test(vHIT), and the caloric test. Abnormal semicircular canal function was defined as an abnormal vHIT or caloric test result. Abnormal saccule function was defined as an abnormal cVEMP. Abnormal utricle function was defined as an abnormal oVEMP. Vestibular function grade Ⅰ was defined when the utricle, saccule, and semicircular canal were normal. Vestibular function grade Ⅱ was defined when the utricle, saccule, or semicircular canal was abnormal. Vestibular function grade Ⅲ was defined when two structures among the utricle, saccule, and semicircular canal were abnormal. Finally, vestibular function grade Ⅳ was defined when the utricle, saccule, and semicircular canal were all abnormal. ResultsWe enrolled 95 cases of MD, including 13, 13, 52, and 17 cases in stages Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively. The pure-tone average(PTA)hearing at 500 Hz, 1 kHz, and 2 kHz was 51.86±21.70 dB HL in the ears with MD. The abnormal rates of cVEMP, oVEMP, vHIT, and caloric test results were 63.2%, 74.7%, 33.7%, and 52.6%, respectively. According to the grade of vestibular function abnormality, 9, 28, 39, and 19 cases were in grades Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively. The vestibular function stage significantly correlated with the PTA(P<0.01, r=0.35), MD stage(P< 0.01, r=0.35), and disease duration(P=0.02, r=0.24). The vestibular function stage did not significantly correlate with patient age(P=0.084). ConclusionThe rates of abnormal otolith and semicircular canal functions increase with the development of MD. Therefore, patients with MD can be accurately assessed with precise testing of the utricle, saccule, and semicircular canals. The status of the development of MD is reflected in the hearing and vestibular function stages. The combined assessment of hearing and vestibular functions can provide a useful reference for the treatment and prognosis of patients with MD.   

  1. Key words: Meniere's disease;
    Vertigo;
    Clinical stage;
    Otolith;
    Semicircular canal;
    Vestibular function;
    Grading
  • Received:2020-07-07 Online:2020-09-20 Published:2020-11-17

摘要: 目的 建立一种新的梅尼埃病患者前庭功能分级方法,初步探索其临床意义及与梅尼埃病听力分期的相关性。 方法 收集112例单侧梅尼埃病患者资料,所有患者均完成包括纯音测听、cVEMP、oVEMP、vHIT以及冷热试验检查。冷热试验和vHIT的结果中任一项异常均视为半规管功能异常。cVEMP结果异常视为球囊功能异常,oVEMP结果异常视为椭圆囊功能异常。球囊、椭圆囊、半规管功能均正常的患者为前庭功能I级,球囊、椭圆囊、半规管功能其中1项异常者为前庭功能Ⅱ级,2项异常者为前庭功能Ⅲ级,3项均异常者为前庭功能Ⅳ级。 结果 根据听力分期,符合入组标准的95例梅尼埃病患者中Ⅰ期13例、Ⅱ期13例、Ⅲ期52例、Ⅳ期17例。患耳平均听阈为(51.86±21.70)dB HL。前庭功能检测结果cVEMP异常率63.2%,oVEMP24异常率74.7%,vHIT异常率33.7%,冷热试验异常率52.6%。前庭功能分级Ⅰ级9例、Ⅱ级28例、Ⅲ级39例、Ⅳ级19例。前庭功能分级与患者的听力差异有统计学意义(P<0.01, r=0.35)。前庭功能分级与患者梅尼埃病分期差异有统计学意义(P<0.01, r=0.35)。前庭功能分级与患者的病程差异有统计学意义(P=0.02, r=0.24)。前庭功能分级与患者的年龄差异无统计学意义(P=0.084)。 结论 梅尼埃病患者随着病程的进展,耳石器功能和半规管功能检测异常率会逐渐增加。通过对球囊、椭圆囊、半规管低频和高频功能的精细化检测,能够对梅尼埃病患者前庭功能进行精准评估。听力分期与前庭功能分级的同步评估能够反映患者疾病的进展状态,同时能够对患者治疗方案的选择和术后康复的预判起到参考作用。

关键词: 梅尼埃病, 眩晕, 临床分期, 耳石器, 半规管, 前庭功能, 分级

Abstract: Objective To establish a new grade of vestibular function abnormality in patients with Menieres disease(MD)and to preliminarily investigate its clinical significance and correlation with the hearing stage. Methods Clinical data of patients with unilateral intractable MD hospitalized from January 2015 to December 2019 were retrospectively reviewed. All patients underwent pure-tone audiometry, cervical vestibular-evoked myogenic potential(cVEMP)testing, ocular VEMP(oVEMP)testing, the video head impulse test(vHIT), and the caloric test. Abnormal semicircular canal function was defined as an abnormal vHIT or caloric test result. Abnormal saccule function was defined as an abnormal cVEMP. Abnormal utricle function was defined as an abnormal oVEMP. Vestibular function grade Ⅰ was defined when the utricle, saccule, and semicircular canal were normal. Vestibular function grade Ⅱ was defined when the utricle, saccule, or semicircular canal was abnormal. Vestibular function grade Ⅲ was defined when two structures among the utricle, saccule, and semicircular canal were abnormal. Finally, vestibular function grade Ⅳ was defined when the utricle, saccule, and semicircular canal were all abnormal. Results We enrolled 95 cases of MD, including 13, 13, 52, and 17 cases in stages Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively. The pure-tone average(PTA)hearing at 500 Hz, 1 kHz, and 2 kHz was 51.86±21.70 dB HL in the ears with MD. The abnormal rates of cVEMP, oVEMP, vHIT, and caloric test results were 63.2%, 74.7%, 33.7%, and 52.6%, respectively. According to the grade of vestibular function abnormality, 9, 28, 39, and 19 cases were in grades Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively. The vestibular function stage significantly correlated with the PTA(P<0.01, r=0.35), MD stage(P< 0.01, r=0.35), and disease duration(P=0.02, r=0.24). The vestibular function stage did not significantly correlate with patient age(P=0.084). Conclusion The rates of abnormal otolith and semicircular canal functions increase with the development of MD. Therefore, patients with MD can be accurately assessed with precise testing of the utricle, saccule, and semicircular canals. The status of the development of MD is reflected in the hearing and vestibular function stages. The combined assessment of hearing and vestibular functions can provide a useful reference for the treatment and prognosis of patients with MD.

Key words: Meniere's disease, Vertigo, Clinical stage, Otolith, Semicircular canal, Vestibular function, Grading

中图分类号: 

  • R764.33
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