亚甲蓝在继发性甲旁亢手术中对甲状旁腺的定位作用

doi:10.6040/j.issn.1673-3770.0.2015.521

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 71-74.doi: 10.6040/j.issn.1673-3770.0.2015.521

亚甲蓝在继发性甲旁亢手术中对甲状旁腺的定位作用

王贝贝¹,杨洪²,欧爱华³

广州中医药大学 1.第二临床医学院;
2. 第二附属医院耳鼻喉头颈外科;
3.第二附属医院临床流行病学室, 广东广州 510000

收稿日期:2015-12-08 出版日期:2016-04-16 发布日期:2016-04-16
通讯作者: 杨洪. E-mail:hong-yang01@163.com E-mail:entdrwang@126.co
作者简介:王贝贝. E-mail:entdrwang@126.co

The role of methylene blue in the localization of parathyroid glands in the operation of secondary hyperparathyroidism.

WANG Beibei¹, YANG Hong², OU Aihua

1. Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 51000, Guangdong, China;2. Department of Otolaryngology &Head and Neck Surgery;3. Department of Clinical Epidemiology, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 51000, Guangdong, China

Received:2015-12-08 Online:2016-04-16 Published:2016-04-16

摘要/Abstract

摘要： 目的探讨亚甲蓝正显影染色法在甲状旁腺全切术中对甲状旁腺的定位作用。方法将49 例行甲状旁腺全切术的继发性甲状旁腺功能亢进(SHPT)患者分为两组,术中静滴亚甲蓝染色定位甲状旁腺25例作为试验组,无任何显影方法辅助24例作为对照组。比较两组手术时间、手术成功率、不良反应发生率、甲状旁腺的检出率及阳性预测值。结果两组比较手术时间、手术成功率差异均有统计学意义(P<0.01,P=0.05);术后发生亚甲蓝相关不良反应分别为1例、0例,差异无统计学意义(P=1.00);检出率分别为99.00%、92.86%,差异有统计学意义(P=0.03);阳性预测值分别为97.06%、91.92%,差异无统计学意义(P=0.11)。结论在继发性甲状旁腺功能亢进症患者行甲状旁腺全切术中,亚甲蓝正显影染色法是快速、安全而有效的定位方法。

关键词: 甲状旁腺, 甲状旁腺切除术, 亚甲蓝, 继发性甲状旁腺功能亢进症

Abstract: Objective To explore the role of the positive development of methylene blue in the localization of parathyroid glands in parathyroidectomy in patients with secondary hyperthyroidism. Methods A total of 49 cases of secondary hyperparathyroidism who would undergo parathyroidectomy were randomly assigned into 2 groups: the experimental group(n=24)in which methylene blue was intravenously dripped, and the control group(n=24)without any developing method. The operation time, success rate of operation, incidence of adverse reactions, detection rate and positive predictive value of parathyroid glands were compared between the two groups. Results The operation time of the experimental group was shorter than that of the control group, the success rate was higher than that of the control group, and the differences were statistically significant(P<0.01, P=0.05). Adverse reactions associated with methylene blue occurred in 1 patient of the experimental group and 0 in the control group, and the difference was not statistically significant (P=1.00). The detection rate of the two groups were 99.00% and 92.86% respectively, with no statistical significance(P=0.03). The positive predictive values of the two groups were 97.06% and 91.92% respectively, with no statistical significance(P=0.11). Conclusion In parathyroidectomy of secondary hyperparathyroidism, methylene blue positive development can quickly, safely and effectively locate the parathyroid glands.

Key words: Secondary hyperparathyroidism, Parathyroidectomy, Parathyroid glands, Methylene blue

中图分类号:

R736.2

王贝贝,杨洪,欧爱华. 亚甲蓝在继发性甲旁亢手术中对甲状旁腺的定位作用[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 71-74.

WANG Beibei, YANG Hong, OU Aihua. The role of methylene blue in the localization of parathyroid glands in the operation of secondary hyperparathyroidism.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 71-74.

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亚甲蓝在继发性甲旁亢手术中对甲状旁腺的定位作用

The role of methylene blue in the localization of parathyroid glands in the operation of secondary hyperparathyroidism.

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